A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer’s Disease in transgenic mice

Amy Craig; Faisal Parvez; Jon Issberner

doi:10.1016/j.bbr.2019.112015

A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer’s Disease in transgenic mice

Amy Craig^*, Faisal Parvez, Jon Issberner

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Clinical implication

Alzheimer’s Disease (AD) presents as a gradual decline in cognitive function, with its characteristic pathology consisting of Amyloid β (Aβ) accumulation and hyperphosphorylated tau. Impaired insulin signalling was recently found in the brain in AD, and shown to increase AD pathology. Similar insulin resistance is found in type 2 diabetes and is currently treated with insulin sensitizers (IS).

Aims and method

The aim of this literature review was to evaluate whether IS could effectively reduce AD’s characteristic pathology and symptoms in models of AD in transgenic mice. The efficacy of an IS (Metformin, Rosiglitazone or Pioglitazone) at improving each characteristic in transgenic mice was evaluated.

Results

A variety of cognitive tests and measures of pathology were utilized to assess these outcomes, hindering comparison. Improvements in cognition, learning and Aβ pathology were demonstrated by some papers, and all papers reported a decrease in tau phosphorylation, but no effect on total tau levels.

Original language	English
Article number	112015
Journal	Behavioural Brain Research
Volume	372
Early online date	27 Jun 2019
DOIs	https://doi.org/10.1016/j.bbr.2019.112015
Publication status	Published - 17 Oct 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Insulin sensitizer
Metformin
Thiazolidinediones
Alzheimer’s disease

Access to Document

10.1016/j.bbr.2019.112015

Craig_2019_BBR_Insulinsensitizers_AAM
Copyright © 2019 Elsevier B.V. All rights reserved. This work is made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1016/j.bbr.2019.112015
Accepted author manuscript, 660 KBLicence: CC BY-NC-ND

Cite this

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title = "A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer{\textquoteright}s Disease in transgenic mice",

abstract = "Clinical implicationAlzheimer{\textquoteright}s Disease (AD) presents as a gradual decline in cognitive function, with its characteristic pathology consisting of Amyloid β (Aβ) accumulation and hyperphosphorylated tau. Impaired insulin signalling was recently found in the brain in AD, and shown to increase AD pathology. Similar insulin resistance is found in type 2 diabetes and is currently treated with insulin sensitizers (IS).Aims and methodThe aim of this literature review was to evaluate whether IS could effectively reduce AD{\textquoteright}s characteristic pathology and symptoms in models of AD in transgenic mice. The efficacy of an IS (Metformin, Rosiglitazone or Pioglitazone) at improving each characteristic in transgenic mice was evaluated.ResultsA variety of cognitive tests and measures of pathology were utilized to assess these outcomes, hindering comparison. Improvements in cognition, learning and Aβ pathology were demonstrated by some papers, and all papers reported a decrease in tau phosphorylation, but no effect on total tau levels.",

keywords = "Insulin sensitizer, Metformin, Thiazolidinediones, Alzheimer{\textquoteright}s disease",

author = "Amy Craig and Faisal Parvez and Jon Issberner",

year = "2019",

month = oct,

day = "17",

doi = "10.1016/j.bbr.2019.112015",

language = "English",

volume = "372",

journal = "Behavioural Brain Research",

issn = "0166-4328",

publisher = "Elsevier",

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TY - JOUR

T1 - A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer’s Disease in transgenic mice

AU - Craig, Amy

AU - Parvez, Faisal

AU - Issberner, Jon

PY - 2019/10/17

Y1 - 2019/10/17

N2 - Clinical implicationAlzheimer’s Disease (AD) presents as a gradual decline in cognitive function, with its characteristic pathology consisting of Amyloid β (Aβ) accumulation and hyperphosphorylated tau. Impaired insulin signalling was recently found in the brain in AD, and shown to increase AD pathology. Similar insulin resistance is found in type 2 diabetes and is currently treated with insulin sensitizers (IS).Aims and methodThe aim of this literature review was to evaluate whether IS could effectively reduce AD’s characteristic pathology and symptoms in models of AD in transgenic mice. The efficacy of an IS (Metformin, Rosiglitazone or Pioglitazone) at improving each characteristic in transgenic mice was evaluated.ResultsA variety of cognitive tests and measures of pathology were utilized to assess these outcomes, hindering comparison. Improvements in cognition, learning and Aβ pathology were demonstrated by some papers, and all papers reported a decrease in tau phosphorylation, but no effect on total tau levels.

AB - Clinical implicationAlzheimer’s Disease (AD) presents as a gradual decline in cognitive function, with its characteristic pathology consisting of Amyloid β (Aβ) accumulation and hyperphosphorylated tau. Impaired insulin signalling was recently found in the brain in AD, and shown to increase AD pathology. Similar insulin resistance is found in type 2 diabetes and is currently treated with insulin sensitizers (IS).Aims and methodThe aim of this literature review was to evaluate whether IS could effectively reduce AD’s characteristic pathology and symptoms in models of AD in transgenic mice. The efficacy of an IS (Metformin, Rosiglitazone or Pioglitazone) at improving each characteristic in transgenic mice was evaluated.ResultsA variety of cognitive tests and measures of pathology were utilized to assess these outcomes, hindering comparison. Improvements in cognition, learning and Aβ pathology were demonstrated by some papers, and all papers reported a decrease in tau phosphorylation, but no effect on total tau levels.

KW - Insulin sensitizer

KW - Metformin

KW - Thiazolidinediones

KW - Alzheimer’s disease

UR - https://www.scopus.com/pages/publications/85068240743

U2 - 10.1016/j.bbr.2019.112015

DO - 10.1016/j.bbr.2019.112015

M3 - Review article

C2 - 31255671

SN - 0166-4328

VL - 372

JO - Behavioural Brain Research

JF - Behavioural Brain Research

M1 - 112015

ER -

A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer’s Disease in transgenic mice

Abstract

UN SDGs

Keywords

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