A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases

J R  Brown; Terry K Smith; M A J  Ferguson; R A  Field

A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases

J R Brown, Terry K Smith, M A J Ferguson, R A Field

Research output: Contribution to journal › Article › peer-review

Abstract

A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage. (C) 1998 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	2051-2054
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	8
Issue number	15
Publication status	Published - 4 Aug 1998

Keywords

PHOSPHATIDYLINOSITOL

Cite this

@article{b823c4e7400940a2a205fdcefbd58f60,

title = "A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases",

abstract = "A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage. (C) 1998 Elsevier Science Ltd. All rights reserved.",

keywords = "PHOSPHATIDYLINOSITOL",

author = "Brown, {J R} and Smith, {Terry K} and Ferguson, {M A J} and Field, {R A}",

year = "1998",

month = aug,

day = "4",

language = "English",

volume = "8",

pages = "2051--2054",

journal = "Bioorganic and Medicinal Chemistry Letters",

publisher = "Elsevier",

number = "15",

}

TY - JOUR

T1 - A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases

AU - Brown, J R

AU - Smith, Terry K

AU - Ferguson, M A J

AU - Field, R A

PY - 1998/8/4

Y1 - 1998/8/4

N2 - A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage. (C) 1998 Elsevier Science Ltd. All rights reserved.

AB - A synthetic analogue of a trisaccharide fragment of the Trypanosoma brucei Variant Surface Glycoprotein (VSG) GlycosylPhosphatidylInositiol (GPI) anchor, Gal-alpha-1,3(Man-alpha-1,6)-Man-alpha-O-octyl (1), serves as a substrate for two T. brucei alpha-galactosyltransferases. The principle tetrasaccharide product derived from (1) contains a Gal-alpha-1,2-Gal linkage. (C) 1998 Elsevier Science Ltd. All rights reserved.

KW - PHOSPHATIDYLINOSITOL

UR - http://www.scopus.com/inward/record.url?scp=0032483111&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 2051

EP - 2054

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

A synthetic acceptor substrate for Trypanosoma brucei UDP-Gal: GPI anchor side-chain alpha-galactosyltransferases

Abstract

Keywords

Other files and links

Fingerprint

Cite this