A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage

Clark D Russell; Ed Whittaker; Dominic P Dee; Eilidh Farquhar; Alba Saenz de Villaverde; Morgan H Evans; Ian F Laurenson; Claire L Mackintosh; Muge Cevik

doi:10.1093/cid/ciaa391

A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage

Clark D Russell, Ed Whittaker, Dominic P Dee, Eilidh Farquhar, Alba Saenz de Villaverde, Morgan H Evans, Ian F Laurenson, Claire L Mackintosh, Muge Cevik

Research output: Contribution to journal › Article › peer-review

Abstract

Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage.

Original language	English
Article number	ciaa391
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	Advance Article
Early online date	8 Apr 2020
DOIs	https://doi.org/10.1093/cid/ciaa391
Publication status	E-pub ahead of print - 8 Apr 2020

Keywords

Hospital-acquired pneumonia
Gram-negative bacteria
Doxycycline
Gentamicin
Antimicrobial stewardship

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/cid/ciaa391Licence: CC BY

Russell-2020-Sub-group-of-patients-with-CID-ciaa391-CCBY
Copyright © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: 10.1093/cid/ciaa391.
Final published version, 150 KBLicence: CC BY

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Russell, C. D., Whittaker, E., Dee, D. P., Farquhar, E., Saenz de Villaverde, A., Evans, M. H., Laurenson, I. F., Mackintosh, C. L., & Cevik, M. (2020). A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage. Clinical Infectious Diseases, Advance Article, Article ciaa391. Advance online publication. https://doi.org/10.1093/cid/ciaa391

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title = "A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage",

abstract = "Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage.",

keywords = "Hospital-acquired pneumonia, Gram-negative bacteria, Doxycycline, Gentamicin, Antimicrobial stewardship",

author = "Russell, {Clark D} and Ed Whittaker and Dee, {Dominic P} and Eilidh Farquhar and {Saenz de Villaverde}, Alba and Evans, {Morgan H} and Laurenson, {Ian F} and Mackintosh, {Claire L} and Muge Cevik",

note = "C.D.R. is supported by an Edinburgh Clinical Academic Track (ECAT)/Wellcome Trust PhD Training Fellowship for Clinicians award (214178/Z/18/Z).",

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doi = "10.1093/cid/ciaa391",

language = "English",

volume = "Advance Article",

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AU - Russell, Clark D

AU - Whittaker, Ed

AU - Dee, Dominic P

AU - Farquhar, Eilidh

AU - Saenz de Villaverde, Alba

AU - Evans, Morgan H

AU - Laurenson, Ian F

AU - Mackintosh, Claire L

AU - Cevik, Muge

N1 - C.D.R. is supported by an Edinburgh Clinical Academic Track (ECAT)/Wellcome Trust PhD Training Fellowship for Clinicians award (214178/Z/18/Z).

PY - 2020/4/8

Y1 - 2020/4/8

N2 - Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage.

AB - Among 200 patients developing hospital-acquired pneumonia (HAP) outside the intensive care unit, 61% were treated empirically without broad-spectrum Gram-negative coverage, with clinical cure in 69.7%. Lower disease severity markers (systemic inflammatory response syndrome, hypoxia, tachypnoea, neutrophilia) and the absence of diabetes mellitus and prior doxycycline treatment (but not the time to HAP onset) identified patients not requiring broad-spectrum Gram-negative coverage.

KW - Hospital-acquired pneumonia

KW - Gram-negative bacteria

KW - Doxycycline

KW - Gentamicin

KW - Antimicrobial stewardship

U2 - 10.1093/cid/ciaa391

DO - 10.1093/cid/ciaa391

M3 - Article

C2 - 32266388

SN - 1058-4838

VL - Advance Article

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

M1 - ciaa391

ER -

A sub-group of patients with hospital-acquired pneumonia do not require broad-spectrum Gram-negative antimicrobial coverage

Abstract

Keywords

UN SDGs

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