Abstract
Direct preparation of tertiary amines in which two substituents are aromatic is described. In the presence of either the inorganic base sodium tert-butoxide or the sterically hindered organic base diisopropylethylamine, the alkylation of secondary diarylamines is achieved smoothly. In contrast to methods previously reported in the literature, this procedure is high-yielding and does not require the use of transition-metal catalysts or functional-group-intolerant hydride reductants.
Original language | English |
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Pages (from-to) | 1046-1051 |
Number of pages | 6 |
Journal | Synthesis |
Volume | 46 |
Issue number | 8 |
DOIs | |
Publication status | Published - Apr 2014 |
Keywords
- tertiary amines
- DIPEA
- alkylation
- benzyl halides
- ARYL CHLORIDES
- ALKYL-HALIDES
- SECONDARY-AMINES
- N-ALKYLATION
- REDUCTION
- AMINATION
- AMIDES
- CATALYSTS
- EFFICIENT
- COMPLEX