A scalable, chromatography-free synthesis of benzotetramisole

David Sydney Bernard Daniels, Siobhan Rose Smith, Tomas Lebl, P. Shapland, Andrew David Smith

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The scalable, chromatography-free synthesis of the chiral isothiourea benzotetramisole (BTM) in two steps from commercially available materials is presented. A detailed procedure for the synthesis of both enantiomers and the racemate on ca. 10 gram scale is disclosed.
Original languageEnglish
Pages (from-to)34-41
JournalSynthesis
Volume47
Issue number1
Early online date21 Nov 2014
DOIs
Publication statusPublished - Jan 2015

Keywords

  • Isothiourea
  • Lewis base catalysis
  • Asymmetric catalysis
  • Kinetic resolution
  • Rearrangement
  • Benzotetramisole

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