A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos

Simmaly Phongmany; Rattanaphone Phetsouvanh; Siho Sisouphone; Chirapha Darasavath; Pankham Vongphachane; Oudayvone Rattanavong; Mayfong Mayxay; Andrew C Ramsay; Stuart D Blacksell; Chanpheng Thammavong; Bounkong Syhavong; Nicholas J White; Paul N Newton

doi:10.1016/j.trstmh.2004.08.007

A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos

Simmaly Phongmany
, Rattanaphone Phetsouvanh
, Siho Sisouphone
, Chirapha Darasavath
, Pankham Vongphachane
, Oudayvone Rattanavong
, Mayfong Mayxay
, Andrew C Ramsay
, Stuart D Blacksell
, Chanpheng Thammavong
, Bounkong Syhavong
, Nicholas J White
, Paul N Newton

Research output: Contribution to journal › Article › peer-review

Abstract

We conducted a randomized open trial of oral chloramphenicol (50mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P<0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost.

Original language	English
Pages (from-to)	451-8
Number of pages	8
Journal	Transactions of the Royal Society of Tropical Medicine and Hygiene
Volume	99
Issue number	6
DOIs	https://doi.org/10.1016/j.trstmh.2004.08.007
Publication status	Published - Jun 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Administration, Oral
Adolescent
Adult
Anti-Bacterial Agents/administration & dosage
Chloramphenicol/administration & dosage
Female
Health Care Costs
Humans
Laos/epidemiology
Male
Microbial Sensitivity Tests
Middle Aged
Ofloxacin/economics
Prospective Studies
Time Factors
Treatment Outcome
Typhoid Fever/drug therapy

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Phongmany, S., Phetsouvanh, R., Sisouphone, S., Darasavath, C., Vongphachane, P., Rattanavong, O., Mayxay, M., Ramsay, A. C., Blacksell, S. D., Thammavong, C., Syhavong, B., White, N. J., & Newton, P. N. (2005). A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos. Transactions of the Royal Society of Tropical Medicine and Hygiene, 99(6), 451-8. https://doi.org/10.1016/j.trstmh.2004.08.007

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title = "A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos",

abstract = "We conducted a randomized open trial of oral chloramphenicol (50mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8\%) were chloramphenicol-resistant and three (6\%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P<0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost.",

keywords = "Administration, Oral, Adolescent, Adult, Anti-Bacterial Agents/administration \& dosage, Chloramphenicol/administration \& dosage, Female, Health Care Costs, Humans, Laos/epidemiology, Male, Microbial Sensitivity Tests, Middle Aged, Ofloxacin/economics, Prospective Studies, Time Factors, Treatment Outcome, Typhoid Fever/drug therapy",

author = "Simmaly Phongmany and Rattanaphone Phetsouvanh and Siho Sisouphone and Chirapha Darasavath and Pankham Vongphachane and Oudayvone Rattanavong and Mayfong Mayxay and Ramsay, \{Andrew C\} and Blacksell, \{Stuart D\} and Chanpheng Thammavong and Bounkong Syhavong and White, \{Nicholas J\} and Newton, \{Paul N\}",

year = "2005",

month = jun,

doi = "10.1016/j.trstmh.2004.08.007",

language = "English",

volume = "99",

pages = "451--8",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

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publisher = "Oxford University Press",

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}

Phongmany, S, Phetsouvanh, R, Sisouphone, S, Darasavath, C, Vongphachane, P, Rattanavong, O, Mayxay, M, Ramsay, AC, Blacksell, SD, Thammavong, C, Syhavong, B, White, NJ & Newton, PN 2005, 'A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos', Transactions of the Royal Society of Tropical Medicine and Hygiene, vol. 99, no. 6, pp. 451-8. https://doi.org/10.1016/j.trstmh.2004.08.007

TY - JOUR

T1 - A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos

AU - Phongmany, Simmaly

AU - Phetsouvanh, Rattanaphone

AU - Sisouphone, Siho

AU - Darasavath, Chirapha

AU - Vongphachane, Pankham

AU - Rattanavong, Oudayvone

AU - Mayxay, Mayfong

AU - Ramsay, Andrew C

AU - Blacksell, Stuart D

AU - Thammavong, Chanpheng

AU - Syhavong, Bounkong

AU - White, Nicholas J

AU - Newton, Paul N

PY - 2005/6

Y1 - 2005/6

N2 - We conducted a randomized open trial of oral chloramphenicol (50mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P<0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost.

AB - We conducted a randomized open trial of oral chloramphenicol (50mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P<0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost.

KW - Administration, Oral

KW - Adolescent

KW - Adult

KW - Anti-Bacterial Agents/administration & dosage

KW - Chloramphenicol/administration & dosage

KW - Female

KW - Health Care Costs

KW - Humans

KW - Laos/epidemiology

KW - Male

KW - Microbial Sensitivity Tests

KW - Middle Aged

KW - Ofloxacin/economics

KW - Prospective Studies

KW - Time Factors

KW - Treatment Outcome

KW - Typhoid Fever/drug therapy

U2 - 10.1016/j.trstmh.2004.08.007

DO - 10.1016/j.trstmh.2004.08.007

M3 - Article

C2 - 15837357

SN - 0035-9203

VL - 99

SP - 451

EP - 458

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

IS - 6

ER -

A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos

Abstract

UN SDGs

Keywords

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