TY - JOUR
T1 - A randomized comparison of oral chloramphenicol versus ofloxacin in the treatment of uncomplicated typhoid fever in Laos
AU - Phongmany, Simmaly
AU - Phetsouvanh, Rattanaphone
AU - Sisouphone, Siho
AU - Darasavath, Chirapha
AU - Vongphachane, Pankham
AU - Rattanavong, Oudayvone
AU - Mayxay, Mayfong
AU - Ramsay, Andrew C
AU - Blacksell, Stuart D
AU - Thammavong, Chanpheng
AU - Syhavong, Bounkong
AU - White, Nicholas J
AU - Newton, Paul N
PY - 2005/6
Y1 - 2005/6
N2 - We conducted a randomized open trial of oral chloramphenicol (50mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P<0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost.
AB - We conducted a randomized open trial of oral chloramphenicol (50mg/kg/day in four divided doses for 14 days) versus ofloxacin (15 mg/kg/day in two divided doses for 3 days) in 50 adults with culture-confirmed uncomplicated typhoid fever in Vientiane, Laos. Patients had been ill for a median (range) of 8 (2-30) days. All Salmonella enterica serotype typhi isolates were nalidixic acid-sensitive, four (8%) were chloramphenicol-resistant and three (6%) were multidrug-resistant. Median (range) fever clearance times were 90 (24-224) hours in the chloramphenicol group and 54 (6-93) hours in the ofloxacin group (P<0.001). One patient in the chloramphenicol group developed an ileal perforation. Three days ofloxacin was more effective than 14 days chloramphenicol for the in-patient treatment of typhoid fever, irrespective of antibiotic susceptibility, and was of similar cost.
KW - Administration, Oral
KW - Adolescent
KW - Adult
KW - Anti-Bacterial Agents/administration & dosage
KW - Chloramphenicol/administration & dosage
KW - Female
KW - Health Care Costs
KW - Humans
KW - Laos/epidemiology
KW - Male
KW - Microbial Sensitivity Tests
KW - Middle Aged
KW - Ofloxacin/economics
KW - Prospective Studies
KW - Time Factors
KW - Treatment Outcome
KW - Typhoid Fever/drug therapy
U2 - 10.1016/j.trstmh.2004.08.007
DO - 10.1016/j.trstmh.2004.08.007
M3 - Article
C2 - 15837357
SN - 0035-9203
VL - 99
SP - 451
EP - 458
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
IS - 6
ER -
