A parcellation scheme for human left lateral parietal cortex

Steven M. Nelson*, Alexander L. Cohen, Jonathan D. Power, Gagan S. Wig, Francis M. Miezin, Mark E. Wheeler, Katerina Velanova, David I. Donaldson, Jeffrey S. Phillips, Bradley L. Schlaggar, Steven E. Petersen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

278 Citations (Scopus)

Abstract

The parietal lobe has long been viewed as a collection of architectonic and functional subdivisions. Though much parietal research has focused on mechanisms of visuospatial attention and control-related processes, more recent functional neuroimaging studies of memory retrieval have reported greater activity in left lateral parietal cortex (LLPC) when items are correctly identified as previously studied (" old" ) versus unstudied (" new" ). These studies have suggested functional divisions within LLPC that may provide distinct contributions toward recognition memory judgments. Here, we define regions within LLPC by developing a parcellation scheme that integrates data from resting-state functional connectivity MRI and functional MRI. This combined approach results in a 6-fold parcellation of LLPC based on the presence (or absence) of memory-retrieval-related activity, dissociations in the profile of task-evoked time courses, and membership in large-scale brain networks. This parcellation should serve as a roadmap for future investigations aimed at understanding LLPC function.

Original languageEnglish
Pages (from-to)156-170
Number of pages15
JournalNeuron
Volume67
Issue number1
DOIs
Publication statusPublished - 1 Jul 2010

Keywords

  • Signaling
  • Sysbio
  • Sysneuro

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