A novel hybrid SCCmec-mecC region in Staphylococcus sciuri

Ewan M Harrison, Gavin K Paterson, Matthew T G Holden, Xiaoliang Ba, Joana Rolo, Fiona J E Morgan, Bruno Pichon, Angela Kearns, Ruth N Zadoks, Sharon J Peacock, Julian Parkhill, Mark A Holmes

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Methicillin resistance in Staphylococcus spp. results from the expression of an alternative penicillin-binding protein 2a (encoded by mecA) with a low affinity for β-lactam antibiotics. Recently, a novel variant of mecA known as mecC (formerly mecALGA251) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified two Staphylococcus sciuri subsp. carnaticus isolates from bovine infections that harbour three different mecA homologues: mecA, mecA1 and mecC.
Original languageEnglish
Pages (from-to)911-918
JournalJournal of Antimicrobial Chemotherapy
Volume69
Issue number4
Early online date2 Dec 2013
DOIs
Publication statusPublished - Apr 2014

Keywords

  • β-lactams
  • MRSA
  • mecA

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