A novel 4.1 ezrin radixin moesin (FERM) containing protein, 'Willin'

Francis James Gunn-Moore; G Welsh; L Herron; F Brannigan; K Venkateswarlu; M Brandwein-Gensler; R Madan; S Gillespie; J Tavare; P Brophy; M Prystowsky; Simon Guild

doi:10.1016/j.febslet.2005.07.097

A novel 4.1 ezrin radixin moesin (FERM) containing protein, 'Willin'

Francis James Gunn-Moore, G Welsh, L Herron, F Brannigan, K Venkateswarlu, M Brandwein-Gensler, R Madan, S Gillespie, J Tavare, P Brophy, M Prystowsky, Simon Guild

Research output: Contribution to journal › Article › peer-review

Abstract

The 4.1 superfamily of proteins contain a 4.1 ezrin radixin moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	5089-5094
Number of pages	6
Journal	FEBS Letters
Volume	579
Issue number	22
DOIs	https://doi.org/10.1016/j.febslet.2005.07.097
Publication status	Published - 12 Sept 2005

Keywords

4.1 ezrin radixin moesin
PLECKSTRIN-HOMOLOGY-DOMAIN
PLASMA-MEMBRANE
PHOSPHATIDYLINOSITOL 3-KINASE
STIMULATED TRANSLOCATION
CELLULAR-DISTRIBUTION
ERM PROTEINS
BINDING-SITE
FERM DOMAIN
EZRIN
CELLS

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10.1016/j.febslet.2005.07.097

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title = "A novel 4.1 ezrin radixin moesin (FERM) containing protein, 'Willin'",

abstract = "The 4.1 superfamily of proteins contain a 4.1 ezrin radixin moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",

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author = "Gunn-Moore, {Francis James} and G Welsh and L Herron and F Brannigan and K Venkateswarlu and M Brandwein-Gensler and R Madan and S Gillespie and J Tavare and P Brophy and M Prystowsky and Simon Guild",

year = "2005",

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doi = "10.1016/j.febslet.2005.07.097",

language = "English",

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T1 - A novel 4.1 ezrin radixin moesin (FERM) containing protein, 'Willin'

AU - Gunn-Moore, Francis James

AU - Welsh, G

AU - Herron, L

AU - Brannigan, F

AU - Venkateswarlu, K

AU - Brandwein-Gensler, M

AU - Madan, R

AU - Gillespie, S

AU - Tavare, J

AU - Brophy, P

AU - Prystowsky, M

AU - Guild, Simon

PY - 2005/9/12

Y1 - 2005/9/12

N2 - The 4.1 superfamily of proteins contain a 4.1 ezrin radixin moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

AB - The 4.1 superfamily of proteins contain a 4.1 ezrin radixin moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

KW - 4.1 ezrin radixin moesin

KW - PLECKSTRIN-HOMOLOGY-DOMAIN

KW - PLASMA-MEMBRANE

KW - PHOSPHATIDYLINOSITOL 3-KINASE

KW - STIMULATED TRANSLOCATION

KW - CELLULAR-DISTRIBUTION

KW - ERM PROTEINS

KW - BINDING-SITE

KW - FERM DOMAIN

KW - EZRIN

KW - CELLS

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U2 - 10.1016/j.febslet.2005.07.097

DO - 10.1016/j.febslet.2005.07.097

M3 - Article

SN - 0014-5793

VL - 579

SP - 5089

EP - 5094

JO - FEBS Letters

JF - FEBS Letters

IS - 22

ER -

A novel 4.1 ezrin radixin moesin (FERM) containing protein, 'Willin'

Abstract

Keywords

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