A novel 4.1 ezrin radixin moesin (FERM) containing protein, 'Willin'

Francis James Gunn-Moore, G Welsh, L Herron, F Brannigan, K Venkateswarlu, M Brandwein-Gensler, R Madan, S Gillespie, J Tavare, P Brophy, M Prystowsky, Simon Guild

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The 4.1 superfamily of proteins contain a 4.1 ezrin radixin moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)5089-5094
Number of pages6
JournalFEBS Letters
Volume579
Issue number22
DOIs
Publication statusPublished - 12 Sept 2005

Keywords

  • 4.1 ezrin radixin moesin
  • PLECKSTRIN-HOMOLOGY-DOMAIN
  • PLASMA-MEMBRANE
  • PHOSPHATIDYLINOSITOL 3-KINASE
  • STIMULATED TRANSLOCATION
  • CELLULAR-DISTRIBUTION
  • ERM PROTEINS
  • BINDING-SITE
  • FERM DOMAIN
  • EZRIN
  • CELLS

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