A new synthetic route to p-methoxy-2,6-disubstituted anilines and their conversion into N-heterocyclic carbene precursors

Sebastien Michel Bernard Meiries; Steven Patrick Nolan

doi:10.1055/s-0033-1340105

A new synthetic route to p-methoxy-2,6-disubstituted anilines and their conversion into N-heterocyclic carbene precursors

Sebastien Michel Bernard Meiries, Steven Patrick Nolan

Research output: Contribution to journal › Letter › peer-review

Abstract

The development of new N-heterocyclic carbenes (NHC) is a key feature in this now mainstream research area to access novel chemical properties and reactivity that are essential for the discovery of original applications. Up to now, only a few reliable methods have proven suitable for the preparation of methoxylated anilines to ultimately access methoxylated NHC. We are pleased to report here a straightforward and scalable approach to address this matter.

Original language	English
Pages (from-to)	393-398
Number of pages	6
Journal	Synlett
Volume	25
Issue number	3
Early online date	3 Dec 2013
DOIs	https://doi.org/10.1055/s-0033-1340105
Publication status	Published - 2014

Keywords

Ligands
Nucleophilic aromatic
Copper
Catalysis
Carbenes

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10.1055/s-0033-1340105

Nolan_2014_Synlett_ANew
© Georg Thieme Verlag Stuttgart · New York
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LSI Collaborative Project: SYNFLOW: EU FP7 Collaborative Project 'SYNFLOW'
Nolan, S. P. (PI) & Cole-Hamilton, D. J. (CoI)
European Commission
1/09/10 → 31/08/14
Project: Standard
Wolfson Research Merit Award: Wolfson Research Merit Award
Nolan, S. P. (PI)
The Royal Society
1/08/10 → 31/07/15
Project: Standard
FUNCAT: EU FP7 ERC Advanced Grant - FUNCAT - Fundamental Studies in Organometallic Chemistry and Homogeneous Catalysis
Nolan, S. P. (PI)
European Research Council
1/01/09 → 31/12/14
Project: Standard

Cite this

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abstract = "The development of new N-heterocyclic carbenes (NHC) is a key feature in this now mainstream research area to access novel chemical properties and reactivity that are essential for the discovery of original applications. Up to now, only a few reliable methods have proven suitable for the preparation of methoxylated anilines to ultimately access methoxylated NHC. We are pleased to report here a straightforward and scalable approach to address this matter.",

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AU - Meiries, Sebastien Michel Bernard

AU - Nolan, Steven Patrick

PY - 2014

Y1 - 2014

N2 - The development of new N-heterocyclic carbenes (NHC) is a key feature in this now mainstream research area to access novel chemical properties and reactivity that are essential for the discovery of original applications. Up to now, only a few reliable methods have proven suitable for the preparation of methoxylated anilines to ultimately access methoxylated NHC. We are pleased to report here a straightforward and scalable approach to address this matter.

AB - The development of new N-heterocyclic carbenes (NHC) is a key feature in this now mainstream research area to access novel chemical properties and reactivity that are essential for the discovery of original applications. Up to now, only a few reliable methods have proven suitable for the preparation of methoxylated anilines to ultimately access methoxylated NHC. We are pleased to report here a straightforward and scalable approach to address this matter.

KW - Ligands

KW - Nucleophilic aromatic

KW - Copper

KW - Catalysis

KW - Carbenes

U2 - 10.1055/s-0033-1340105

DO - 10.1055/s-0033-1340105

M3 - Letter

SN - 0936-5214

VL - 25

SP - 393

EP - 398

JO - Synlett

JF - Synlett

IS - 3

ER -

A new synthetic route to p-methoxy-2,6-disubstituted anilines and their conversion into N-heterocyclic carbene precursors

Abstract

Keywords

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Projects

LSI Collaborative Project: SYNFLOW: EU FP7 Collaborative Project 'SYNFLOW'

Wolfson Research Merit Award: Wolfson Research Merit Award

FUNCAT: EU FP7 ERC Advanced Grant - FUNCAT - Fundamental Studies in Organometallic Chemistry and Homogeneous Catalysis

Cite this