A new short synthesis of coumestrol and its application for the synthesis of [6,6a,11a-13C3]coumestrol

Nawaf Al-Maharik, Nigel Peter Botting

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

A convenient and simple two-step method for the synthesis of coumestrol has been established, which involves a base catalysed condensation of phenyl acetate with benzoyl chloride, followed by demethylation and subsequent tandem intramolecular cyclisation. This method was then employed for the efficient synthesis of multiply C-13-labelled coumestrol. (C) 2003 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1637-1642
Number of pages6
JournalTetrahedron
Volume60
Issue number7
DOIs
Publication statusPublished - 9 Feb 2004

Keywords

  • coumestrol
  • coumestans
  • pterocarpans
  • phytoestrogens
  • C-13-labelling
  • MASS-SPECTROMETRY
  • QUANTIFICATION
  • ISOFLAVONOIDS
  • LIGNANS

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