Abstract
A method for the syntheses of E-unsaturated acyclic nucleosides via a combination of palladium-catalyzed allylic alkylation and ruthenium-based cross metathesis is described. This approach provides a concise, efficient and reliable route to new nucleoside analogues. (C) 2003 Elsevier Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 9177-9180 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 44 |
| Issue number | 51 |
| DOIs | |
| Publication status | Published - 15 Dec 2003 |
Keywords
- palladium-mediated allylic alkylation
- cross-metathesis
- acyclonucleosides
- RING-CLOSING METATHESIS
- L-CYCLOPENTENONE DERIVATIVES
- CARBOCYCLIC NUCLEOSIDES
- ENANTIOSELECTIVE SYNTHESIS
- ASYMMETRIC-SYNTHESIS
- CLOSURE METATHESIS
- OLEFIN METATHESIS
- EFFICIENT
- 9-(2-HYDROXYETHOXYMETHYL)GUANINE
- ANALOGS
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