A new route to acyclic nucleosides via palladium-mediated allylic alkylation and cross-metathesis

F Amblard, Steven Patrick Nolan, I Gillaizeau, L A Agrofoglio

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26 Citations (Scopus)

Abstract

A method for the syntheses of E-unsaturated acyclic nucleosides via a combination of palladium-catalyzed allylic alkylation and ruthenium-based cross metathesis is described. This approach provides a concise, efficient and reliable route to new nucleoside analogues. (C) 2003 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)9177-9180
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number51
DOIs
Publication statusPublished - 15 Dec 2003

Keywords

  • palladium-mediated allylic alkylation
  • cross-metathesis
  • acyclonucleosides
  • RING-CLOSING METATHESIS
  • L-CYCLOPENTENONE DERIVATIVES
  • CARBOCYCLIC NUCLEOSIDES
  • ENANTIOSELECTIVE SYNTHESIS
  • ASYMMETRIC-SYNTHESIS
  • CLOSURE METATHESIS
  • OLEFIN METATHESIS
  • EFFICIENT
  • 9-(2-HYDROXYETHOXYMETHYL)GUANINE
  • ANALOGS

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