A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang; Agnieszka Kulczynska; David J. Webb; Ian L. Megson; Nigel P. Botting

doi:10.1039/c2cc38382a

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

Qingzhi Zhang^*, Agnieszka Kulczynska, David J. Webb, Ian L. Megson, Nigel P. Botting

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

Original language	English
Pages (from-to)	1389-1391
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	14
Early online date	21 Dec 2012
DOIs	https://doi.org/10.1039/c2cc38382a
Publication status	Published - 2013

Keywords

Nitric-oxide synthases
Cardiac-surgery
rat-kidney
Injury
Hydroxyguanidines
Failure
Oxidation
Strategy
Prodrugs
DOPA

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10.1039/c2cc38382a

Zhang-c2cc38382a
© Royal Society of Chemistry 2013. This is an open access article, available from http://pubs.rsc.org
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title = "A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation",

abstract = "This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).",

keywords = "Nitric-oxide synthases, Cardiac-surgery, rat-kidney, Injury, Hydroxyguanidines, Failure, Oxidation, Strategy, Prodrugs, DOPA",

author = "Qingzhi Zhang and Agnieszka Kulczynska and Webb, {David J.} and Megson, {Ian L.} and Botting, {Nigel P.}",

note = "The authors are grateful to the Wellcome Trust (Catalyst Biomedica Development Award 063729/Z/01/Z) for financial support.",

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AU - Kulczynska, Agnieszka

AU - Webb, David J.

AU - Megson, Ian L.

AU - Botting, Nigel P.

N1 - The authors are grateful to the Wellcome Trust (Catalyst Biomedica Development Award 063729/Z/01/Z) for financial support.

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AB - This communication describes the synthesis of a new class of N-hydroxyguanidine (NHG) pro-drugs which release nitric oxide (NO), triggered by the action of gamma-glutamyl transpeptidase (gamma-GT), and have potential for the treatment of acute renal injury/failure (ARI/ARF).

KW - Nitric-oxide synthases

KW - Cardiac-surgery

KW - rat-kidney

KW - Injury

KW - Hydroxyguanidines

KW - Failure

KW - Oxidation

KW - Strategy

KW - Prodrugs

KW - DOPA

U2 - 10.1039/c2cc38382a

DO - 10.1039/c2cc38382a

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JO - Chemical Communications

JF - Chemical Communications

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ER -

A new class of NO-donor pro-drugs triggered by γ-glutamyl transpeptidase with potential for reno-selective vasodilatation

Abstract

Keywords

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