TY - JOUR
T1 - A nearly-neutral biallelic Moran model with biased mutation and linear and quadratic selection
AU - Vogl, Claus
AU - Mikula, Lynette Caitlin
N1 - CV’s research is supported by the Austrian Science Fund (FWF): DK W1225-B20; LCM’s by the School of Biology at the University of St.Andrews and has been partially funded through Vienna Science and Technology Fund (WWTF), Austria [MA016-061].
PY - 2021/6
Y1 - 2021/6
N2 - In this article, a biallelic reversible mutation model with linear and quadratic selection is analysed. The approach reconnects to one proposed by Kimura (1979), who starts from a diffusion model and derives its equilibrium distribution up to a constant. We use a boundary-mutation Moran model, which approximates a general mutation model for small effective mutation rates, and derive its equilibrium distribution for polymorphic and monomorphic variants in small to moderately sized populations. Using this model, we show that biased mutation rates and linear selection alone can cause patterns of polymorphism within and substitution rates between populations that are usually ascribed to balancing or overdominant selection. We illustrate this using a data set of short introns and fourfold degenerate sites from Drosophila simulans and Drosophila melanogaster.
AB - In this article, a biallelic reversible mutation model with linear and quadratic selection is analysed. The approach reconnects to one proposed by Kimura (1979), who starts from a diffusion model and derives its equilibrium distribution up to a constant. We use a boundary-mutation Moran model, which approximates a general mutation model for small effective mutation rates, and derive its equilibrium distribution for polymorphic and monomorphic variants in small to moderately sized populations. Using this model, we show that biased mutation rates and linear selection alone can cause patterns of polymorphism within and substitution rates between populations that are usually ascribed to balancing or overdominant selection. We illustrate this using a data set of short introns and fourfold degenerate sites from Drosophila simulans and Drosophila melanogaster.
KW - Linear and quadratic selection
KW - McDonald–Kreitman test
KW - Moran model
KW - Mutation bias
KW - Mutation–selection–drift equilibrium
KW - Nearly-neutral theory
U2 - 10.1016/j.tpb.2021.03.003
DO - 10.1016/j.tpb.2021.03.003
M3 - Article
C2 - 33964284
SN - 0040-5809
VL - 139
SP - 1
EP - 17
JO - Theoretical Population Biology
JF - Theoretical Population Biology
ER -