A multicomponent route to functionalized amides and oxazolidinones

Christopher G. McPherson, Alasdair K. Cooper, Andrius Bubliauskas, Paul Mulrainey, Craig Jamieson, Allan J. B. Watson

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


An organobase-mediated, multicomponent reaction of unactivated esters, epoxides, and amines is reported, furnishing functionalized amide derivatives. A wide range of substrates are tolerated under the reaction conditions, including chiral epoxides, which react with no erosion of enantiopurity. Facile modification of the method, through replacing the ester derivative with dimethyl carbonate, enables access to the corresponding oxazolidinone derivatives.
Original languageEnglish
Pages (from-to)6736-6739
JournalOrganic Letters
Issue number24
Early online date1 Dec 2017
Publication statusPublished - 15 Dec 2017


Dive into the research topics of 'A multicomponent route to functionalized amides and oxazolidinones'. Together they form a unique fingerprint.

Cite this