TY - JOUR
T1 - A multicomponent route to functionalized amides and oxazolidinones
AU - McPherson, Christopher G.
AU - Cooper, Alasdair K.
AU - Bubliauskas, Andrius
AU - Mulrainey, Paul
AU - Jamieson, Craig
AU - Watson, Allan J. B.
N1 - We thank the University of Strathclyde for financial support.
PY - 2017/12/15
Y1 - 2017/12/15
N2 - An organobase-mediated, multicomponent reaction of unactivated esters, epoxides, and amines is reported, furnishing functionalized amide derivatives. A wide range of substrates are tolerated under the reaction conditions, including chiral epoxides, which react with no erosion of enantiopurity. Facile modification of the method, through replacing the ester derivative with dimethyl carbonate, enables access to the corresponding oxazolidinone derivatives.
AB - An organobase-mediated, multicomponent reaction of unactivated esters, epoxides, and amines is reported, furnishing functionalized amide derivatives. A wide range of substrates are tolerated under the reaction conditions, including chiral epoxides, which react with no erosion of enantiopurity. Facile modification of the method, through replacing the ester derivative with dimethyl carbonate, enables access to the corresponding oxazolidinone derivatives.
U2 - 10.1021/acs.orglett.7b03470
DO - 10.1021/acs.orglett.7b03470
M3 - Article
SN - 1523-7060
VL - 19
SP - 6736
EP - 6739
JO - Organic Letters
JF - Organic Letters
IS - 24
ER -