A multicomponent route to functionalized amides and oxazolidinones

Christopher G. McPherson, Alasdair K. Cooper, Andrius Bubliauskas, Paul Mulrainey, Craig Jamieson, Allan J. B. Watson

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

An organobase-mediated, multicomponent reaction of unactivated esters, epoxides, and amines is reported, furnishing functionalized amide derivatives. A wide range of substrates are tolerated under the reaction conditions, including chiral epoxides, which react with no erosion of enantiopurity. Facile modification of the method, through replacing the ester derivative with dimethyl carbonate, enables access to the corresponding oxazolidinone derivatives.
Original languageEnglish
Pages (from-to)6736-6739
JournalOrganic Letters
Volume19
Issue number24
Early online date1 Dec 2017
DOIs
Publication statusPublished - 15 Dec 2017

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