A molecular mechanism for modulating plasma Zn speciation by fatty acids

Jin Lu, Alan J. Stewart, Darrell Sleep, Peter J. Sadler, Teresa J. T. Pinheiro, Claudia A. Blindauer

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to an high-affinity inter-domain site that disrupts at least one Zn site. Albumin may be a molecular device to "translate" certain aspects of the organismal energy state into global zinc signals.
Original languageEnglish
Pages (from-to)1454-1457
Number of pages4
JournalJournal of the American Chemical Society
Issue number3
Early online date4 Jan 2012
Publication statusPublished - 25 Jan 2012


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