A highly enantioselective alkene methoxycarbonylation enables a concise synthesis of (S)-flurbiprofen

Gavin J. Harkness, Matthew Lee Clarke

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A highly enantioselective synthesis of (S)-Flurbiprofen methyl ester in two steps from commercially available 4-bromo-2-fluoro-1,1'-biphenyl is shown. [PdCl2((S)-Xylyl-Phanephos)] catalyst is used to accomplish both Grignard cross-coupling and the highly enantioselective intermolecular methoxycarbonylation reaction.
Original languageEnglish
Pages (from-to)4859-4863
Number of pages5
JournalEuropean Journal of Organic Chemistry
Volume2017
Issue number32
Early online date31 Aug 2017
DOIs
Publication statusPublished - 1 Sept 2017

Keywords

  • Palladium
  • Asymmetric catalysis
  • Carbonylation
  • Hydroesterification
  • Hydroxycarbonylation

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