A highly active manganese catalyst for enantioselective ketone and ester hydrogenation

Magnus B. Widegren; Gavin J. Harkness; Alexandra M. Z. Slawin; David B. Cordes; Matthew L. Clarke

doi:10.1002/anie.201702406

A highly active manganese catalyst for enantioselective ketone and ester hydrogenation

Magnus B. Widegren, Gavin J. Harkness, Alexandra M. Z. Slawin, David B. Cordes, Matthew L. Clarke^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A new hydrogenation catalyst based onamanganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% ee in the hydrogenation of pro-chiral deactivated ketones at 30-50 degrees C.

Original language	English
Pages (from-to)	5825-5828
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	56
Issue number	21
Early online date	20 Apr 2017
DOIs	https://doi.org/10.1002/anie.201702406
Publication status	Published - 8 May 2017

Keywords

Enantioselective catalysis
Ester hydrogenation
Ferrocene
Manganese
Reduction

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10.1002/anie.201702406

Widegren_2017_Manganese_ACIE_AAM
© 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with publisher policies or with permission. Permission for further reuse of this content should be sought from the publisher or the rights holder. This is the author created accepted manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at https://doi.org/10.1002/anie.201702406
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http://hdl.handle.net/10023/13175

Matt Clarke
- mc28st-andrews.acuk
- School of Chemistry - Professor (Research Focused)
- EaSTCHEM
Person: Academic - Research

A highly active manganese catalyst for the hydrogenation of ketones and esters: enantioselective reduction catalysis with manganese (dataset)
Widegren, M. B. (Creator), Clarke, M. L. (Creator), Harkness, G. J. (Creator), Slawin, A. M. Z. (Creator) & Cordes, D. B. (Creator), University of St Andrews, 25 Apr 2017
DOI: 10.17630/91ab7775-867c-4b21-97c7-7c9117269ada
Dataset

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2 Article

A highly active manganese catalyst for enantioselective ketone and ester hydrogenation
Widegren, M. B., Harkness, G. J., Slawin, A. M. Z., Cordes, D. B. & Clarke, M. L., 15 May 2017, In: Angewandte Chemie. 129, 21, p. 5919-5922 4 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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Corrigendum: A highly active manganese catalyst for enantioselective ketone and ester hydrogenation (Angew. Chem. Int. Ed. (2017), 56, (5825-5828), 10.1002/anie.201702406)
Widegren, M. B., Harkness, G. J., Slawin, A. M. Z., Cordes, D. B. & Clarke, M. L., 27 Jul 2017, In: Angewandte Chemie - International Edition. 56, 32
Research output: Contribution to journal › Article › peer-review

Cite this

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title = "A highly active manganese catalyst for enantioselective ketone and ester hydrogenation",

abstract = "A new hydrogenation catalyst based onamanganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% ee in the hydrogenation of pro-chiral deactivated ketones at 30-50 degrees C.",

keywords = "Enantioselective catalysis, Ester hydrogenation, Ferrocene, Manganese, Reduction",

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AU - Harkness, Gavin J.

AU - Slawin, Alexandra M. Z.

AU - Cordes, David B.

AU - Clarke, Matthew L.

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KW - Enantioselective catalysis

KW - Ester hydrogenation

KW - Ferrocene

KW - Manganese

KW - Reduction

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A highly active manganese catalyst for enantioselective ketone and ester hydrogenation

Abstract

Keywords

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Matt Clarke

Datasets

A highly active manganese catalyst for the hydrogenation of ketones and esters: enantioselective reduction catalysis with manganese (dataset)

Research output

A highly active manganese catalyst for enantioselective ketone and ester hydrogenation

Corrigendum: A highly active manganese catalyst for enantioselective ketone and ester hydrogenation (Angew. Chem. Int. Ed. (2017), 56, (5825-5828), 10.1002/anie.201702406)

Cite this