A highly active manganese catalyst for enantioselective ketone and ester hydrogenation

Magnus B. Widegren, Gavin J. Harkness, Alexandra M. Z. Slawin, David B. Cordes, Matthew L. Clarke*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

133 Citations (Scopus)
1 Downloads (Pure)

Abstract

A new hydrogenation catalyst based onamanganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% ee in the hydrogenation of pro-chiral deactivated ketones at 30-50 degrees C.

Original languageEnglish
Pages (from-to)5825-5828
Number of pages4
JournalAngewandte Chemie International Edition
Volume56
Issue number21
Early online date20 Apr 2017
DOIs
Publication statusPublished - 8 May 2017

Keywords

  • Enantioselective catalysis
  • Ester hydrogenation
  • Ferrocene
  • Manganese
  • Reduction

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