A highly active manganese catalyst for enantioselective ketone and ester hydrogenation

Magnus B. Widegren; Gavin J. Harkness; Alexandra M. Z. Slawin; David B. Cordes; Matthew L. Clarke

doi:10.1002/ange.201702406

A highly active manganese catalyst for enantioselective ketone and ester hydrogenation

Magnus B. Widegren, Gavin J. Harkness, Alexandra M. Z. Slawin, David B. Cordes, Matthew L. Clarke

Research output: Contribution to journal › Article › peer-review

Abstract

A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% e.e. in the hydrogenation of pro-chiral deactivated ketones at 30-50 ^oC.

Original language	English
Pages (from-to)	5919-5922
Number of pages	4
Journal	Angewandte Chemie
Volume	129
Issue number	21
Early online date	20 Apr 2017
DOIs	https://doi.org/10.1002/ange.201702406
Publication status	Published - 15 May 2017

Keywords

Manganese
Reduction
Ester hydrogenation
Ferrocene
Enantioselective catalysis

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10.1002/ange.201702406

Widegren_2017_Manganese_ACIE_AAM
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This work has been made available online in accordance with the publisher’s policies. This is the author created, accepted version manuscript following peer review and may differ slightly from the final published version. The final published version of this work is available at: https://doi.org/10.1002/anie.201702406
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title = "A highly active manganese catalyst for enantioselective ketone and ester hydrogenation",

abstract = "A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% e.e. in the hydrogenation of pro-chiral deactivated ketones at 30-50 oC.",

keywords = "Manganese, Reduction, Ester hydrogenation, Ferrocene, Enantioselective catalysis",

author = "Widegren, {Magnus B.} and Harkness, {Gavin J.} and Slawin, {Alexandra M. Z.} and Cordes, {David B.} and Clarke, {Matthew L.}",

note = "We thank the EPSRC for DTG funding for M.B.W. and G.J.H. and for the use of the National Mass Spectrometry Service. The technical support staff at St Andrews are also gratefully acknowledged. The research data underpinning this paper can be accessed at: https://doi.org/10.17630/91ab7775-867c-4b21-97c7-7c9117269ada.",

year = "2017",

month = may,

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language = "English",

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T1 - A highly active manganese catalyst for enantioselective ketone and ester hydrogenation

AU - Widegren, Magnus B.

AU - Harkness, Gavin J.

AU - Slawin, Alexandra M. Z.

AU - Cordes, David B.

AU - Clarke, Matthew L.

N1 - We thank the EPSRC for DTG funding for M.B.W. and G.J.H. and for the use of the National Mass Spectrometry Service. The technical support staff at St Andrews are also gratefully acknowledged. The research data underpinning this paper can be accessed at: https://doi.org/10.17630/91ab7775-867c-4b21-97c7-7c9117269ada.

PY - 2017/5/15

Y1 - 2017/5/15

N2 - A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% e.e. in the hydrogenation of pro-chiral deactivated ketones at 30-50 oC.

AB - A new hydrogenation catalyst based on a manganese complex of a chiral P,N,N ligand has been found to be especially active for the hydrogenation of esters down to 0.1 mol% catalyst loading, and gives up to 97% e.e. in the hydrogenation of pro-chiral deactivated ketones at 30-50 oC.

KW - Manganese

KW - Reduction

KW - Ester hydrogenation

KW - Ferrocene

KW - Enantioselective catalysis

UR - http://onlinelibrary.wiley.com/doi/10.1002/ange.201702406/full#footer-support-info

U2 - 10.1002/ange.201702406

DO - 10.1002/ange.201702406

M3 - Article

SN - 0044-8249

VL - 129

SP - 5919

EP - 5922

JO - Angewandte Chemie

JF - Angewandte Chemie

IS - 21

ER -

A highly active manganese catalyst for enantioselective ketone and ester hydrogenation

Abstract

Keywords

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A highly active manganese catalyst for the hydrogenation of ketones and esters: enantioselective reduction catalysis with manganese (dataset)