A gene’s-eye view of sexual antagonism

Thomas Hitchcock*, Andy Gardner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)
1 Downloads (Pure)

Abstract

Females and males may face different selection pressures. Accordingly, alleles that confer a benefit for one sex often incur a cost for the other. Classic evolutionary theory holds that the X chromosome, whose sex-biased transmission sees it spending more time in females, should value females more than males, whereas autosomes, whose transmission is unbiased, should value both sexes equally. However, recent mathematical and empirical studies indicate that male-beneficial alleles may be more favoured by the X chromosome than by autosomes. Here we develop a gene's-eye-view approach that reconciles the classic view with these recent discordant results, by separating a gene's valuation of female versus male fitness from its ability to induce fitness effects in either sex. We use this framework to generate new comparative predictions for sexually antagonistic evolution in relation to dosage compensation, sex-specific mortality and assortative mating, revealing how molecular mechanisms, ecology and demography drive variation in masculinization versus feminization across the genome.
Original languageEnglish
Article number20201633
Number of pages9
JournalProceedings of the Royal Society of London Series B: Biological Sciences
Volume287
Issue number1932
DOIs
Publication statusPublished - 12 Aug 2020

Keywords

  • Age structure
  • Assortative mating
  • Dosage compensation
  • Intragenomic conflict
  • Sexual antagonism
  • Sex chromosome
  • Inclusive fitness

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