A GENERAL METHODOLOGY FOR THE SYNTHESIS OF SUBSTITUTED PHENOLS FROM PYRANONE PRECURSORS

Laura J. Marshall, Karl M. Cable, Nigel P. Botting

Research output: Contribution to journalArticlepeer-review

Abstract

Phenols are an important group of organic compounds,(1) with many natural products such as polyketides, coumarins and flavonoids containing mono- or poly-phenolic moieties. The synthesis of substituted phenols from pyranone precursors is presented. A variety of pronucleophiles were used in combination with tert-butanol as solvent and potassium tert-butoxide as base, using both conventional heating methods and microwave conditions.

Original languageEnglish
Pages (from-to)457-459
Number of pages3
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume53
Issue number5-6
Publication statusPublished - 15 May 2010

Keywords

  • phenol
  • pyranone
  • maltol
  • chelidonic acid
  • pronucleophile
  • ACID

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