A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

S M  Allin; C J  Northfield; M I  Page; A M Z  Slawin

A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

S M Allin, C J Northfield, M I Page, A M Z Slawin

Research output: Contribution to journal › Article › peer-review

Abstract

A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate. (C) 1998 Elsevier Science Ltd. All rights reserved.

Original language	English
Pages (from-to)	4905-4908
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	27
Publication status	Published - 2 Jul 1998

Keywords

ENANTIOSELECTIVE TOTAL SYNTHESES
ALKALOIDS
ISOINDOLOBENZAZEPINE
(+/-)-NUEVAMINE
DERIVATIVES

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title = "A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction",

abstract = "A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate. (C) 1998 Elsevier Science Ltd. All rights reserved.",

keywords = "ENANTIOSELECTIVE TOTAL SYNTHESES, ALKALOIDS, ISOINDOLOBENZAZEPINE, (+/-)-NUEVAMINE, DERIVATIVES",

author = "Allin, {S M} and Northfield, {C J} and Page, {M I} and Slawin, {A M Z}",

year = "1998",

month = jul,

day = "2",

language = "English",

volume = "39",

pages = "4905--4908",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

AU - Allin, S M

AU - Northfield, C J

AU - Page, M I

AU - Slawin, A M Z

PY - 1998/7/2

Y1 - 1998/7/2

N2 - A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate. (C) 1998 Elsevier Science Ltd. All rights reserved.

AB - A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate. (C) 1998 Elsevier Science Ltd. All rights reserved.

KW - ENANTIOSELECTIVE TOTAL SYNTHESES

KW - ALKALOIDS

KW - ISOINDOLOBENZAZEPINE

KW - (+/-)-NUEVAMINE

KW - DERIVATIVES

M3 - Article

SN - 0040-4039

VL - 39

SP - 4905

EP - 4908

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 27

ER -

A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

Abstract

Keywords

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