A Staphylococcus xylosus Isolate with a new mecC Allotype

Ewan M. Harrison; Gavin K. Paterson; Matthew T. G. Holden; Fiona J. E. Morgan; Anders Rhod Larsen; Andreas Petersen; Sabine Leroy; Sarne De Vliegher; Vincent Perreten; Lawrence K. Fox; Theo J. G. M. Lam; Otlis C. Sampimon; Ruth N. Zadoks; Sharon J. Peacock; Julian Parkhill; Mark A. Holmes

doi:10.1128/AAC.01882-12

A Staphylococcus xylosus Isolate with a new mecC Allotype

Ewan M. Harrison
, Gavin K. Paterson
, Matthew T. G. Holden
, Fiona J. E. Morgan
, Anders Rhod Larsen
, Andreas Petersen
, Sabine Leroy
, Sarne De Vliegher
, Vincent Perreten
, Lawrence K. Fox
, Theo J. G. M. Lam
, Otlis C. Sampimon
, Ruth N. Zadoks
, Sharon J. Peacock
, Julian Parkhill
, Mark A. Holmes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.

Original language	English
Pages (from-to)	1524-1528
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01882-12
Publication status	Published - Mar 2013

Keywords

COAGULASE-NEGATIVE STAPHYLOCOCCI
PENICILLIN-BINDING PROTEIN
BETA-LACTAM RESISTANCE
ANTIBIOTIC-RESISTANCE
ENTEROCOCCUS-FAECALIS
GENETIC HOMOLOG
MULTIPLEX PCR
AUREUS
METHICILLIN
MECA(LGA251)

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Harrison, E. M., Paterson, G. K., Holden, M. T. G., Morgan, F. J. E., Larsen, A. R., Petersen, A., Leroy, S., De Vliegher, S., Perreten, V., Fox, L. K., Lam, T. J. G. M., Sampimon, O. C., Zadoks, R. N., Peacock, S. J., Parkhill, J., & Holmes, M. A. (2013). A Staphylococcus xylosus Isolate with a new mecC Allotype. Antimicrobial Agents and Chemotherapy, 57(3), 1524-1528. https://doi.org/10.1128/AAC.01882-12

@article{d8bdeb63c3ae4b92babda021cac96a71,

title = "A Staphylococcus xylosus Isolate with a new mecC Allotype",

abstract = "Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.",

keywords = "COAGULASE-NEGATIVE STAPHYLOCOCCI, PENICILLIN-BINDING PROTEIN, BETA-LACTAM RESISTANCE, ANTIBIOTIC-RESISTANCE, ENTEROCOCCUS-FAECALIS, GENETIC HOMOLOG, MULTIPLEX PCR, AUREUS, METHICILLIN, MECA(LGA251)",

author = "Harrison, \{Ewan M.\} and Paterson, \{Gavin K.\} and Holden, \{Matthew T. G.\} and Morgan, \{Fiona J. E.\} and Larsen, \{Anders Rhod\} and Andreas Petersen and Sabine Leroy and \{De Vliegher\}, Sarne and Vincent Perreten and Fox, \{Lawrence K.\} and Lam, \{Theo J. G. M.\} and Sampimon, \{Otlis C.\} and Zadoks, \{Ruth N.\} and Peacock, \{Sharon J.\} and Julian Parkhill and Holmes, \{Mark A.\}",

year = "2013",

month = mar,

doi = "10.1128/AAC.01882-12",

language = "English",

volume = "57",

pages = "1524--1528",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "3",

}

Harrison, EM, Paterson, GK, Holden, MTG, Morgan, FJE, Larsen, AR, Petersen, A, Leroy, S, De Vliegher, S, Perreten, V, Fox, LK, Lam, TJGM, Sampimon, OC, Zadoks, RN, Peacock, SJ, Parkhill, J & Holmes, MA 2013, 'A Staphylococcus xylosus Isolate with a new mecC Allotype', Antimicrobial Agents and Chemotherapy, vol. 57, no. 3, pp. 1524-1528. https://doi.org/10.1128/AAC.01882-12

TY - JOUR

T1 - A Staphylococcus xylosus Isolate with a new mecC Allotype

AU - Harrison, Ewan M.

AU - Paterson, Gavin K.

AU - Holden, Matthew T. G.

AU - Morgan, Fiona J. E.

AU - Larsen, Anders Rhod

AU - Petersen, Andreas

AU - Leroy, Sabine

AU - De Vliegher, Sarne

AU - Perreten, Vincent

AU - Fox, Lawrence K.

AU - Lam, Theo J. G. M.

AU - Sampimon, Otlis C.

AU - Zadoks, Ruth N.

AU - Peacock, Sharon J.

AU - Parkhill, Julian

AU - Holmes, Mark A.

PY - 2013/3

Y1 - 2013/3

N2 - Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.

AB - Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.

KW - COAGULASE-NEGATIVE STAPHYLOCOCCI

KW - PENICILLIN-BINDING PROTEIN

KW - BETA-LACTAM RESISTANCE

KW - ANTIBIOTIC-RESISTANCE

KW - ENTEROCOCCUS-FAECALIS

KW - GENETIC HOMOLOG

KW - MULTIPLEX PCR

KW - AUREUS

KW - METHICILLIN

KW - MECA(LGA251)

U2 - 10.1128/AAC.01882-12

DO - 10.1128/AAC.01882-12

M3 - Article

SN - 0066-4804

VL - 57

SP - 1524

EP - 1528

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

ER -

A Staphylococcus xylosus Isolate with a new mecC Allotype

Abstract

Keywords

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