A Staphylococcus xylosus Isolate with a new mecC Allotype

Ewan M. Harrison, Gavin K. Paterson, Matthew T. G. Holden, Fiona J. E. Morgan, Anders Rhod Larsen, Andreas Petersen, Sabine Leroy, Sarne De Vliegher, Vincent Perreten, Lawrence K. Fox, Theo J. G. M. Lam, Otlis C. Sampimon, Ruth N. Zadoks, Sharon J. Peacock, Julian Parkhill, Mark A. Holmes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.

Original languageEnglish
Pages (from-to)1524-1528
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume57
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • COAGULASE-NEGATIVE STAPHYLOCOCCI
  • PENICILLIN-BINDING PROTEIN
  • BETA-LACTAM RESISTANCE
  • ANTIBIOTIC-RESISTANCE
  • ENTEROCOCCUS-FAECALIS
  • GENETIC HOMOLOG
  • MULTIPLEX PCR
  • AUREUS
  • METHICILLIN
  • MECA(LGA251)

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