A Staphylococcus xylosus Isolate with a new mecC Allotype

Ewan M. Harrison; Gavin K. Paterson; Matthew T. G. Holden; Fiona J. E. Morgan; Anders Rhod Larsen; Andreas Petersen; Sabine Leroy; Sarne De Vliegher; Vincent Perreten; Lawrence K. Fox; Theo J. G. M. Lam; Otlis C. Sampimon; Ruth N. Zadoks; Sharon J. Peacock; Julian Parkhill; Mark A. Holmes

doi:10.1128/AAC.01882-12

A Staphylococcus xylosus Isolate with a new mecC Allotype

Ewan M. Harrison, Gavin K. Paterson, Matthew T. G. Holden, Fiona J. E. Morgan, Anders Rhod Larsen, Andreas Petersen, Sabine Leroy, Sarne De Vliegher, Vincent Perreten, Lawrence K. Fox, Theo J. G. M. Lam, Otlis C. Sampimon, Ruth N. Zadoks, Sharon J. Peacock, Julian Parkhill, Mark A. Holmes^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.

Original language	English
Pages (from-to)	1524-1528
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	57
Issue number	3
DOIs	https://doi.org/10.1128/AAC.01882-12
Publication status	Published - Mar 2013

Keywords

COAGULASE-NEGATIVE STAPHYLOCOCCI
PENICILLIN-BINDING PROTEIN
BETA-LACTAM RESISTANCE
ANTIBIOTIC-RESISTANCE
ENTEROCOCCUS-FAECALIS
GENETIC HOMOLOG
MULTIPLEX PCR
AUREUS
METHICILLIN
MECA(LGA251)

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Harrison, E. M., Paterson, G. K., Holden, M. T. G., Morgan, F. J. E., Larsen, A. R., Petersen, A., Leroy, S., De Vliegher, S., Perreten, V., Fox, L. K., Lam, T. J. G. M., Sampimon, O. C., Zadoks, R. N., Peacock, S. J., Parkhill, J., & Holmes, M. A. (2013). A Staphylococcus xylosus Isolate with a new mecC Allotype. Antimicrobial Agents and Chemotherapy, 57(3), 1524-1528. https://doi.org/10.1128/AAC.01882-12

@article{d8bdeb63c3ae4b92babda021cac96a71,

title = "A Staphylococcus xylosus Isolate with a new mecC Allotype",

abstract = "Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.",

keywords = "COAGULASE-NEGATIVE STAPHYLOCOCCI, PENICILLIN-BINDING PROTEIN, BETA-LACTAM RESISTANCE, ANTIBIOTIC-RESISTANCE, ENTEROCOCCUS-FAECALIS, GENETIC HOMOLOG, MULTIPLEX PCR, AUREUS, METHICILLIN, MECA(LGA251)",

author = "Harrison, {Ewan M.} and Paterson, {Gavin K.} and Holden, {Matthew T. G.} and Morgan, {Fiona J. E.} and Larsen, {Anders Rhod} and Andreas Petersen and Sabine Leroy and {De Vliegher}, Sarne and Vincent Perreten and Fox, {Lawrence K.} and Lam, {Theo J. G. M.} and Sampimon, {Otlis C.} and Zadoks, {Ruth N.} and Peacock, {Sharon J.} and Julian Parkhill and Holmes, {Mark A.}",

year = "2013",

month = mar,

doi = "10.1128/AAC.01882-12",

language = "English",

volume = "57",

pages = "1524--1528",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "3",

}

Harrison, EM, Paterson, GK, Holden, MTG, Morgan, FJE, Larsen, AR, Petersen, A, Leroy, S, De Vliegher, S, Perreten, V, Fox, LK, Lam, TJGM, Sampimon, OC, Zadoks, RN, Peacock, SJ, Parkhill, J & Holmes, MA 2013, 'A Staphylococcus xylosus Isolate with a new mecC Allotype', Antimicrobial Agents and Chemotherapy, vol. 57, no. 3, pp. 1524-1528. https://doi.org/10.1128/AAC.01882-12

TY - JOUR

T1 - A Staphylococcus xylosus Isolate with a new mecC Allotype

AU - Harrison, Ewan M.

AU - Paterson, Gavin K.

AU - Holden, Matthew T. G.

AU - Morgan, Fiona J. E.

AU - Larsen, Anders Rhod

AU - Petersen, Andreas

AU - Leroy, Sabine

AU - De Vliegher, Sarne

AU - Perreten, Vincent

AU - Fox, Lawrence K.

AU - Lam, Theo J. G. M.

AU - Sampimon, Otlis C.

AU - Zadoks, Ruth N.

AU - Peacock, Sharon J.

AU - Parkhill, Julian

AU - Holmes, Mark A.

PY - 2013/3

Y1 - 2013/3

N2 - Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.

AB - Recently, a novel variant of mecA known as mecC (mecA(LGA251)) was identified in Staphylococcus aureus isolates from both humans and animals. In this study, we identified a Staphylococcus xylosus isolate that harbors a new allotype of the mecC gene, mecC1. Whole-genome sequencing revealed that mecC1 forms part of a class E mec complex (mecI-mecR1-mecC1-blaZ) located at the orfX locus as part of a likely staphylococcal cassette chromosome mec element (SCCmec) remnant, which also contains a number of other genes present on the type XI SCCmec.

KW - COAGULASE-NEGATIVE STAPHYLOCOCCI

KW - PENICILLIN-BINDING PROTEIN

KW - BETA-LACTAM RESISTANCE

KW - ANTIBIOTIC-RESISTANCE

KW - ENTEROCOCCUS-FAECALIS

KW - GENETIC HOMOLOG

KW - MULTIPLEX PCR

KW - AUREUS

KW - METHICILLIN

KW - MECA(LGA251)

U2 - 10.1128/AAC.01882-12

DO - 10.1128/AAC.01882-12

M3 - Article

SN - 0066-4804

VL - 57

SP - 1524

EP - 1528

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 3

ER -

A Staphylococcus xylosus Isolate with a new mecC Allotype

Abstract

Keywords

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