A DFT study on the origin of the fluorine gauche effect in substituted fluoroethanes

David Y. Buissonneaud, Tanja van Mourik, David O'Hagan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)

Abstract

DFT derived conformational energy profiles of a series of beta-substituted alpha-fluoroethanes (F-CH(2)CH(2)-X) have been explored where the substituent X was varied as NH(3)(+), OCOH, NCO, NO(2), NHCHO, F, N(3), CH=NH, NCS, CH=C=CH(2), CH(3), CH=CH(2), NC, CN, CHO, and CCH Comparisons were correlated relative to 1,2-difluoroethane. a compound which exhibits a well known gauche preference Only four of the compounds displayed an ann preference, with the large majority preferring a gauche conformation In particular the influence of steric and electrostatic attraction/repulsion between the fluorine atom and the X-substituent was explored by evaluating rotational energy profiles for all compounds and separately NBO correlations were evaluated to assess the contribution of hyperconjugation to the minimised gauche and ann conformers In the event the gauche preference for 1,2-difluoroethane was shown to have all origin due largely to sigma(C-H)->sigma*(C-F) hyperconjugative interactions, whereas the conformational preference for the remaining structures is rationalised by hyperconjugative as well as steric and electrostatic contributions The anti preferred compounds 13, 14 and 16 possessed triple bonds and the preference arose Clue to fluorine/p-orbital repulsion (C) 2010 Published by Elsevier Ltd

Original languageEnglish
Pages (from-to)2196-2202
Number of pages7
JournalTetrahedron
Volume66
Issue number12
DOIs
Publication statusPublished - 20 Mar 2010

Keywords

  • 1,2-DIFLUOROETHANE
  • ORIENTATION
  • STERIC REPULSION
  • CONFORMATIONAL-ANALYSIS
  • ELECTRON LOCALIZATION
  • HYPERCONJUGATION
  • DENSITY
  • 3-FLUOROPIPERIDINES
  • C-F BOND
  • THERMOCHEMISTRY

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