A cooperative Pd-Cu system for direct C-H bond arylation

Mathieu Lesieur; Faima Lazreg; Catherine S. J. Cazin

doi:10.1039/c4cc03201b

A cooperative Pd-Cu system for direct C-H bond arylation

Mathieu Lesieur, Faima Lazreg, Catherine S. J. Cazin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed. This process promotes the challenging construction of C-C bonds from arenes or heteroarenes using aryl bromides and chlorides. Mechanistic studies show that [Cu(OH)(NHC)] plays a key role in the C-H activation and is involved in the transmetallation with the Pd-NHC co-catalyst.

Original language	English
Pages (from-to)	8927-8929
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	64
Early online date	30 Jun 2014
DOIs	https://doi.org/10.1039/c4cc03201b
Publication status	Published - 18 Aug 2014

Keywords

Cross-coupling reactions
Suzuki-Miyaura
Vinyl halides
Palladium
Complexes
Reagents
Catalyst
Substitutions
Heteroarenes
Activation

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10.1039/c4cc03201b

c4cc03201b
Copyright 2014 The Authors. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/)
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title = "A cooperative Pd-Cu system for direct C-H bond arylation",

abstract = "A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed. This process promotes the challenging construction of C-C bonds from arenes or heteroarenes using aryl bromides and chlorides. Mechanistic studies show that [Cu(OH)(NHC)] plays a key role in the C-H activation and is involved in the transmetallation with the Pd-NHC co-catalyst.",

keywords = "Cross-coupling reactions, Suzuki-Miyaura, Vinyl halides, Palladium, Complexes, Reagents, Catalyst, Substitutions, Heteroarenes, Activation",

author = "Mathieu Lesieur and Faima Lazreg and Cazin, {Catherine S. J.}",

note = "The authors are grateful to the Royal Society (University Research Fellowship to CSJC) for financial support. ",

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doi = "10.1039/c4cc03201b",

language = "English",

volume = "50",

pages = "8927--8929",

journal = "Chemical Communications",

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T1 - A cooperative Pd-Cu system for direct C-H bond arylation

AU - Lesieur, Mathieu

AU - Lazreg, Faima

AU - Cazin, Catherine S. J.

N1 - The authors are grateful to the Royal Society (University Research Fellowship to CSJC) for financial support.

PY - 2014/8/18

Y1 - 2014/8/18

N2 - A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed. This process promotes the challenging construction of C-C bonds from arenes or heteroarenes using aryl bromides and chlorides. Mechanistic studies show that [Cu(OH)(NHC)] plays a key role in the C-H activation and is involved in the transmetallation with the Pd-NHC co-catalyst.

AB - A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed. This process promotes the challenging construction of C-C bonds from arenes or heteroarenes using aryl bromides and chlorides. Mechanistic studies show that [Cu(OH)(NHC)] plays a key role in the C-H activation and is involved in the transmetallation with the Pd-NHC co-catalyst.

KW - Cross-coupling reactions

KW - Suzuki-Miyaura

KW - Vinyl halides

KW - Palladium

KW - Complexes

KW - Reagents

KW - Catalyst

KW - Substitutions

KW - Heteroarenes

KW - Activation

UR - http://www.rsc.org/suppdata/cc/c4/c4cc03201b/c4cc03201b1.pdf

U2 - 10.1039/c4cc03201b

DO - 10.1039/c4cc03201b

M3 - Article

SN - 1359-7345

VL - 50

SP - 8927

EP - 8929

JO - Chemical Communications

JF - Chemical Communications

IS - 64

ER -

A cooperative Pd-Cu system for direct C-H bond arylation

Abstract

Keywords

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