A cooperative Pd-Cu system for direct C-H bond arylation

Mathieu Lesieur, Faima Lazreg, Catherine S. J. Cazin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


A novel and efficient method for C-H arylation using well-defined Pd- and Cu-NHC systems has been developed. This process promotes the challenging construction of C-C bonds from arenes or heteroarenes using aryl bromides and chlorides. Mechanistic studies show that [Cu(OH)(NHC)] plays a key role in the C-H activation and is involved in the transmetallation with the Pd-NHC co-catalyst.

Original languageEnglish
Pages (from-to)8927-8929
Number of pages3
JournalChemical Communications
Issue number64
Early online date30 Jun 2014
Publication statusPublished - 18 Aug 2014


  • Cross-coupling reactions
  • Suzuki-Miyaura
  • Vinyl halides
  • Palladium
  • Complexes
  • Reagents
  • Catalyst
  • Substitutions
  • Heteroarenes
  • Activation


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