A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

Michael Winn; Abhijeet Deb Roy; Sabine Grueschow; Raj S. Parameswaran; Rebecca J. M. Goss

doi:10.1016/j.bmcl.2008.07.053

A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

Michael Winn
, Abhijeet Deb Roy
, Sabine Grueschow
, Raj S. Parameswaran
, Rebecca J. M. Goss^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A one-pot biotransformation for the generation of a series of L-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity. (c) 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	4508-4510
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2008.07.053
Publication status	Published - 15 Aug 2008

Keywords

DESIGN
STATE
GENETIC-CODE
preparation
TRYPTOPHAN SYNTHASE
halotryptophan
aminotryptophan
biotransformation
tryptophan synthase
ANTIBIOTICS

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10.1016/j.bmcl.2008.07.053

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@article{6943ff73f271490ea2ab6445dcd6e220,

title = "A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan",

abstract = "A one-pot biotransformation for the generation of a series of L-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity. (c) 2008 Elsevier Ltd. All rights reserved.",

keywords = "DESIGN, STATE, GENETIC-CODE, preparation, TRYPTOPHAN SYNTHASE, halotryptophan, aminotryptophan, biotransformation, tryptophan synthase, ANTIBIOTICS",

author = "Michael Winn and Roy, \{Abhijeet Deb\} and Sabine Grueschow and Parameswaran, \{Raj S.\} and Goss, \{Rebecca J. M.\}",

year = "2008",

month = aug,

day = "15",

doi = "10.1016/j.bmcl.2008.07.053",

language = "English",

volume = "18",

pages = "4508--4510",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

number = "16",

}

TY - JOUR

T1 - A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

AU - Winn, Michael

AU - Roy, Abhijeet Deb

AU - Grueschow, Sabine

AU - Parameswaran, Raj S.

AU - Goss, Rebecca J. M.

PY - 2008/8/15

Y1 - 2008/8/15

N2 - A one-pot biotransformation for the generation of a series of L-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity. (c) 2008 Elsevier Ltd. All rights reserved.

AB - A one-pot biotransformation for the generation of a series of L-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity. (c) 2008 Elsevier Ltd. All rights reserved.

KW - DESIGN

KW - STATE

KW - GENETIC-CODE

KW - preparation

KW - TRYPTOPHAN SYNTHASE

KW - halotryptophan

KW - aminotryptophan

KW - biotransformation

KW - tryptophan synthase

KW - ANTIBIOTICS

U2 - 10.1016/j.bmcl.2008.07.053

DO - 10.1016/j.bmcl.2008.07.053

M3 - Article

SN - 0960-894X

VL - 18

SP - 4508

EP - 4510

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -

A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

Abstract

Keywords

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