A convenient one-step synthesis of L-aminotryptophans and improved synthesis of 5-fluorotryptophan

Michael Winn, Abhijeet Deb Roy, Sabine Grueschow, Raj S. Parameswaran, Rebecca J. M. Goss*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

A one-pot biotransformation for the generation of a series of L-aminotryptophans using a readily prepared protein extract containing tryptophan synthase is reported. The extract exhibits remarkable stability upon freeze-drying, and may be stored and used for long periods after its preparation without significant loss of activity. (c) 2008 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)4508-4510
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number16
DOIs
Publication statusPublished - 15 Aug 2008

Keywords

  • DESIGN
  • STATE
  • GENETIC-CODE
  • preparation
  • TRYPTOPHAN SYNTHASE
  • halotryptophan
  • aminotryptophan
  • biotransformation
  • tryptophan synthase
  • ANTIBIOTICS

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