A consecutive process for C–C and C–N bond formation with high enantio-and diastereocontrol: direct reductive amination of chiral ketones using hydrogenation catalysts

Sophie H. Gilbert, Virginie Viseur, Matthew L. Clarke

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
3 Downloads (Pure)

Abstract

High diastereoselectivity was observed in the Rh-catalysed reductive amination of 3-arylcyclohexanones to form tertiary amines. This was incorporated into a one-pot enantioselective conjugate addition and diastereoselective reductive amination, including an example of assisted tandem catalysis.
Original languageEnglish
Pages (from-to)6409-6412
Number of pages4
JournalChemical Communications
Volume55
Issue number45
Early online date10 May 2019
DOIs
Publication statusPublished - 7 Jun 2019

Keywords

  • Asymmetric hydrogenation
  • Reductive amination
  • Homogeneous catalysis

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