A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications

Samantha E. Russell; Juan María González Carballo; Claudia Orellana-Tavra; David Fairen-Jimenez; Russell E. Morris

doi:10.1039/C7DT00195A

A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications

Samantha E. Russell^*
, Juan María González Carballo
, Claudia Orellana-Tavra
, David Fairen-Jimenez
, Russell E. Morris

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Copper-exchanged and acidic zeolites are shown to produce nitric oxide (NO) from a nitrite source in biologically active (nanomolar) concentrations. Four zeolites were studied; mordenite, ferrierite, ZSM-5 and SSZ-13, which had varying pore size, channel systems and Si/Al ratios. ZSM-5 and SSZ-13 produced the highest amounts of NO in both the copper and acid form. The high activity and regeneration of the copper active sites makes them good candidates for long-term NO production. Initial cytotoxicity tests have shown at least one of the copper zeolites (Cu-SSZ-13) to be biocompatible, highlighting the potential usage within biomedical applications.

Original language	English
Pages (from-to)	3915-3920
Number of pages	6
Journal	Dalton Transactions
Volume	46
Issue number	12
Early online date	28 Mar 2017
DOIs	https://doi.org/10.1039/C7DT00195A
Publication status	Published - 28 Mar 2017

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10.1039/C7DT00195A

Morris_2017_DT_BiomedApplications_AAM
© 2017 Authors. This work has been made available online in accordance with the publisher’s policies. This is the author created accepted version manuscript following peer review and as such may differ slightly from the final published version. The final published version of this work is available at: https://doi.org/ 10.1039/C7DT00195A
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CRITICAT - Delivery of Teach & Training: CRITICAT - Delivery of Teaching & Technical Training
Smith, A. (PI)
EPSRC
1/05/14 → 31/10/22
Project: Standard

Zeolite Catalysts for Nitric Oxide Production (Thesis Data)
Russell, S. (Creator) & Morris, R. E. (Supervisor), University of St Andrews, 2020
DOI: 10.17630/d62c8236-0b6f-4d2d-9e79-227d7e8e2d5d, http://hdl.handle.net/10023/17918
Dataset: Thesis dataset

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Zeolite catalysts for nitric oxide production
Russell, S. (Author), Morris, R. (Supervisor), 26 Jun 2019
Student thesis: Doctoral Thesis (PhD)

Cite this

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title = "A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications",

abstract = "Copper-exchanged and acidic zeolites are shown to produce nitric oxide (NO) from a nitrite source in biologically active (nanomolar) concentrations. Four zeolites were studied; mordenite, ferrierite, ZSM-5 and SSZ-13, which had varying pore size, channel systems and Si/Al ratios. ZSM-5 and SSZ-13 produced the highest amounts of NO in both the copper and acid form. The high activity and regeneration of the copper active sites makes them good candidates for long-term NO production. Initial cytotoxicity tests have shown at least one of the copper zeolites (Cu-SSZ-13) to be biocompatible, highlighting the potential usage within biomedical applications.",

author = "Russell, \{Samantha E.\} and \{Gonz{\'a}lez Carballo\}, \{Juan Mar{\'i}a\} and Claudia Orellana-Tavra and David Fairen-Jimenez and Morris, \{Russell E.\}",

note = "The authors would like to thank the Engineering and Physical Sciences Research Council, University of St Andrews, and CRITICAT Centre for Doctoral Training for financial support [Ph.D. studentship to SR; Grant code: EP/L016419/1]. C. A. O. thanks Becas Chile and the Cambridge Trust for funding. D. F.-J. thanks the Royal Society (UK) for funding through a University Research Fellowship. Thanks also go to Chevron for the sample of H-SSZ-13.",

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AU - Fairen-Jimenez, David

AU - Morris, Russell E.

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AB - Copper-exchanged and acidic zeolites are shown to produce nitric oxide (NO) from a nitrite source in biologically active (nanomolar) concentrations. Four zeolites were studied; mordenite, ferrierite, ZSM-5 and SSZ-13, which had varying pore size, channel systems and Si/Al ratios. ZSM-5 and SSZ-13 produced the highest amounts of NO in both the copper and acid form. The high activity and regeneration of the copper active sites makes them good candidates for long-term NO production. Initial cytotoxicity tests have shown at least one of the copper zeolites (Cu-SSZ-13) to be biocompatible, highlighting the potential usage within biomedical applications.

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JO - Dalton Transactions

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A comparison of copper and acid site zeolites for the production of nitric oxide for biomedical applications

Abstract

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Projects

CRITICAT - Delivery of Teach & Training: CRITICAT - Delivery of Teaching & Technical Training

Datasets

Zeolite Catalysts for Nitric Oxide Production (Thesis Data)

Student theses

Zeolite catalysts for nitric oxide production

Cite this