A Clean and Selective Radical Homocoupling Employing Carboxylic Acids with Titania Photoredox Catalysis

David W. Manley, John C. Walton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)
1 Downloads (Pure)

Abstract

A titania photoredox catalysis protocol was developed for the homocoupling of C-centered radicals derived from carboxylic acids. Intermolecular reactions were generally efficient and selective, furnishing the desired dimers in good yields under mild neutral conditions. Selective cross-coupling with two acids proved unsuccessful. An intramolecular adaptation enabled macrocycles to be prepared, albeit in modest yields.

Original languageEnglish
Pages (from-to)5394-5397
Number of pages4
JournalOrganic Letters
Volume16
Issue number20
Early online date7 Oct 2014
DOIs
Publication statusPublished - 17 Oct 2014

Keywords

  • Coupling-reactions
  • Organic-synthesis
  • Natural-products
  • Tertiary-amines
  • Polymerizations
  • Photocatalysis
  • Alkylations

Fingerprint

Dive into the research topics of 'A Clean and Selective Radical Homocoupling Employing Carboxylic Acids with Titania Photoredox Catalysis'. Together they form a unique fingerprint.

Cite this