TY - JOUR
T1 - A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols
AU - Fernandez Salas, Jose Antonio
AU - Manzini, Simone
AU - Nolan, Steven Patrick
PY - 2014
Y1 - 2014
N2 - A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantio enriched acetates in a one-pot reaction, probing the versatility of complex 2.
AB - A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantio enriched acetates in a one-pot reaction, probing the versatility of complex 2.
UR - https://www.scopus.com/pages/publications/84941083043
U2 - 10.1002/chem.201404096
DO - 10.1002/chem.201404096
M3 - Article
SN - 0947-6539
VL - 20
SP - 13132
EP - 13135
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
ER -