A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols

Jose Antonio Fernandez Salas, Simone Manzini, Steven Patrick Nolan

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantio enriched acetates in a one-pot reaction, probing the versatility of complex 2.
Original languageEnglish
Pages (from-to)13132-13135
Number of pages4
JournalChemistry - A European Journal
Volume20
Early online date28 Aug 2014
DOIs
Publication statusPublished - 2014

Fingerprint

Dive into the research topics of 'A Cationic Ruthenium Complex for the Dynamic Kinetic Resolution of Secondary Alcohols'. Together they form a unique fingerprint.

Cite this