Abstract
A synthetic protocol making use of a well-defined cationic ruthenium complex 2 enabling the racemization of enantiomerically pure secondary alcohols in the presence of a weak base (K2CO3) is described. The compatibility of 2 with Candida Antarctica lipase B (Novozym 435) allows the development of an efficient dynamic kinetic resolution of sec-alcohols in the absence of an additional strong base. This procedure involves the first example of a dynamic kinetic resolution of alcohols in the presence of a cationic ruthenium catalyst. In addition, we describe the conversion of ketones to the enantio enriched acetates in a one-pot reaction, probing the versatility of complex 2.
| Original language | English |
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| Pages (from-to) | 13132-13135 |
| Number of pages | 4 |
| Journal | Chemistry - A European Journal |
| Volume | 20 |
| Early online date | 28 Aug 2014 |
| DOIs | |
| Publication status | Published - 2014 |