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The catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea tetramisole. An acidic workup proved necessary to minimize product epimerization and maximize product er, providing cis-chromenones in excellent yield, and with excellent diastereo- and enantioselectivity.
FingerprintDive into the research topics of '6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis'. Together they form a unique fingerprint.
- 2 Finished
1/05/14 → 31/10/22
data underpinning "6-exo-trig Michael Addition-Lactonizations for Catalytic Enantioselective Chromenone Synthesis"