6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The catalytic enantioselective 6-exo-trig Michael addition-lactonization of enone-acid substrates to form cis-chromenones with high diastereo- and enantiocontrol was developed using the commercially available isothiourea tetramisole. An acidic workup proved necessary to minimize product epimerization and maximize product er, providing cis-chromenones in excellent yield, and with excellent diastereo- and enantioselectivity.
Original languageEnglish
Pages (from-to)2555-2558
JournalChemical Communications
Volume53
Issue number17
Early online date19 Jan 2017
DOIs
Publication statusPublished - 28 Feb 2017

Fingerprint

Dive into the research topics of '6-exo-trig Michael addition-lactonizations for catalytic enantioselective chromenone synthesis'. Together they form a unique fingerprint.

Cite this