4-Substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors

I Churcher; D Beher; JD Best; JL Castro; EE Clarke; A Gentry; T Harrison; L Hitzel; E Kay; S Kerrad; HD Lewis; P Morentin-Gutierrez; R Mortishire-Smith; PJ Oakley; M Reilly; DE Shaw; MS Shearman; MR Teall; S Williams; JDJ Wrigley

doi:10.1016/j.bmcl.2005.10.009

4-Substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors

I Churcher, D Beher, JD Best, JL Castro, EE Clarke, A Gentry, T Harrison, L Hitzel, E Kay, S Kerrad, HD Lewis, P Morentin-Gutierrez, R Mortishire-Smith, PJ Oakley, M Reilly, DE Shaw, MS Shearman, MR Teall, S Williams, JDJ Wrigley

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	280-284
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/j.bmcl.2005.10.009
Publication status	Published - 15 Jan 2006

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10.1016/j.bmcl.2005.10.009

Cite this

Churcher, I., Beher, D., Best, JD., Castro, JL., Clarke, EE., Gentry, A., Harrison, T., Hitzel, L., Kay, E., Kerrad, S., Lewis, HD., Morentin-Gutierrez, P., Mortishire-Smith, R., Oakley, PJ., Reilly, M., Shaw, DE., Shearman, MS., Teall, MR., Williams, S., & Wrigley, JDJ. (2006). 4-Substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors. Bioorganic and Medicinal Chemistry Letters, 16(2), 280-284. https://doi.org/10.1016/j.bmcl.2005.10.009

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title = "4-Substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors",

author = "I Churcher and D Beher and JD Best and JL Castro and EE Clarke and A Gentry and T Harrison and L Hitzel and E Kay and S Kerrad and HD Lewis and P Morentin-Gutierrez and R Mortishire-Smith and PJ Oakley and M Reilly and DE Shaw and MS Shearman and MR Teall and S Williams and JDJ Wrigley",

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Churcher, I, Beher, D, Best, JD, Castro, JL, Clarke, EE, Gentry, A, Harrison, T, Hitzel, L, Kay, E, Kerrad, S, Lewis, HD, Morentin-Gutierrez, P, Mortishire-Smith, R, Oakley, PJ, Reilly, M, Shaw, DE, Shearman, MS, Teall, MR, Williams, S & Wrigley, JDJ 2006, '4-Substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors', Bioorganic and Medicinal Chemistry Letters, vol. 16, no. 2, pp. 280-284. https://doi.org/10.1016/j.bmcl.2005.10.009

TY - JOUR

T1 - 4-Substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors

AU - Churcher, I

AU - Beher, D

AU - Best, JD

AU - Castro, JL

AU - Clarke, EE

AU - Gentry, A

AU - Harrison, T

AU - Hitzel, L

AU - Kay, E

AU - Kerrad, S

AU - Lewis, HD

AU - Morentin-Gutierrez, P

AU - Mortishire-Smith, R

AU - Oakley, PJ

AU - Reilly, M

AU - Shaw, DE

AU - Shearman, MS

AU - Teall, MR

AU - Williams, S

AU - Wrigley, JDJ

PY - 2006/1/15

Y1 - 2006/1/15

U2 - 10.1016/j.bmcl.2005.10.009

DO - 10.1016/j.bmcl.2005.10.009

M3 - Article

VL - 16

SP - 280

EP - 284

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -