4′-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics

Phillip T. Lowe*, David O’Hagan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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The history and development of 4′-fluoro-nucleosides is discussed in this review. This is a class of nucleosides which have their origin in the discovery of the rare fluorine containing natural product nucleocidin. Nucleocidin contains a fluorine atom located at the 4′-position of its ribose ring. From its early isolation as an unexpected natural product, to its total synthesis and bioactivity assessment, nucleocidin has played a role in inspiring the exploration of 4′-fluoro-nucleosides as a privileged motif for nucleoside-based therapeutics.
Original languageEnglish
Pages (from-to)248-276
Number of pages29
JournalChemical Society Reviews
Issue number1
Early online date6 Dec 2022
Publication statusPublished - 7 Jan 2023


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