3D Monte Carlo radiation transfer modelling of photodynamic therapy

Catherine Louise Campbell; C. Christison; C Tom A Brown; Kenny Wood; Ronan Martin Valentine; H. Moseley

doi:10.1117/12.2180744

3D Monte Carlo radiation transfer modelling of photodynamic therapy

Catherine Louise Campbell, C. Christison, C Tom A Brown, Kenny Wood, Ronan Martin Valentine, H. Moseley

School of Physics and Astronomy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

Original language	English
Title of host publication	Biophotonics South America
Editors	Christina Kurachi, Katarina Svanberg, Bruce J. Tromberg, Vanderlei S. Bagnato
Publisher	SPIE
ISBN (Print)	9781628416961
DOIs	https://doi.org/10.1117/12.2180744
Publication status	Published - Jun 2015
Event	Biophotonics South America - Rio de Janeiro, Brazil Duration: 23 May 2015 → …

Publication series

Name	Proceedings of SPIE
Volume	9531
ISSN (Print)	1605-7422

Conference

Conference	Biophotonics South America
Country/Territory	Brazil
City	Rio de Janeiro
Period	23/05/15 → …

Access to Document

10.1117/12.2180744

Brown_2015_SPIE_3DMonte
Copyright 2015 Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. Originally published by SPIE here: http://dx.doi.org/10.1117/12.2180744
Final published version, 664 KB

Cite this

@inproceedings{af9f556fa21f46388a42ab28fd280b47,

title = "3D Monte Carlo radiation transfer modelling of photodynamic therapy",

abstract = "The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.",

author = "Campbell, \{Catherine Louise\} and C. Christison and Brown, \{C Tom A\} and Kenny Wood and Valentine, \{Ronan Martin\} and H. Moseley",

note = "We acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell as well as the Alfred Stewart Trust.; Biophotonics South America ; Conference date: 23-05-2015",

year = "2015",

month = jun,

doi = "10.1117/12.2180744",

language = "English",

isbn = "9781628416961",

series = "Proceedings of SPIE",

publisher = "SPIE",

editor = "Christina Kurachi and Katarina Svanberg and Tromberg, \{Bruce J.\} and Bagnato, \{Vanderlei S.\}",

booktitle = "Biophotonics South America",

address = "United States",

}

Campbell, CL, Christison, C, Brown, CTA , Wood, K, Valentine, RM & Moseley, H 2015, 3D Monte Carlo radiation transfer modelling of photodynamic therapy. in C Kurachi, K Svanberg, BJ Tromberg & VS Bagnato (eds), Biophotonics South America. Proceedings of SPIE, vol. 9531, SPIE, Biophotonics South America, Rio de Janeiro, Brazil, 23/05/15. https://doi.org/10.1117/12.2180744

3D Monte Carlo radiation transfer modelling of photodynamic therapy. / Campbell, Catherine Louise; Christison, C.; Brown, C Tom A et al.
Biophotonics South America. ed. / Christina Kurachi; Katarina Svanberg; Bruce J. Tromberg; Vanderlei S. Bagnato. SPIE, 2015. (Proceedings of SPIE; Vol. 9531).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - 3D Monte Carlo radiation transfer modelling of photodynamic therapy

AU - Campbell, Catherine Louise

AU - Christison, C.

AU - Brown, C Tom A

AU - Wood, Kenny

AU - Valentine, Ronan Martin

AU - Moseley, H.

N1 - We acknowledge the support of the UK Engineering and Physics Sciences Research Council (EPSRC) for funding through a studentship for C L Campbell as well as the Alfred Stewart Trust.

PY - 2015/6

Y1 - 2015/6

N2 - The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

AB - The effects of ageing and skin type on Photodynamic Therapy (PDT) for different treatment methods have been theoretically investigated. A multilayered Monte Carlo Radiation Transfer model is presented where both daylight activated PDT and conventional PDT are compared. It was found that light penetrates deeper through older skin with a lighter complexion, which translates into a deeper effective treatment depth. The effect of ageing was found to be larger for darker skin types. The investigation further strengthens the usage of daylight as a potential light source for PDT where effective treatment depths of about 2 mm can be achieved.

UR - https://www.scopus.com/pages/publications/84938942933

U2 - 10.1117/12.2180744

DO - 10.1117/12.2180744

M3 - Conference contribution

AN - SCOPUS:84938942933

SN - 9781628416961

T3 - Proceedings of SPIE

BT - Biophotonics South America

A2 - Kurachi, Christina

A2 - Svanberg, Katarina

A2 - Tromberg, Bruce J.

A2 - Bagnato, Vanderlei S.

PB - SPIE

T2 - Biophotonics South America

Y2 - 23 May 2015

ER -

3D Monte Carlo radiation transfer modelling of photodynamic therapy

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Astrophysics at St Andrews:2012 - 2014: Astrophysics at St Andrews: 2012 - 2014

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3D Monte Carlo radiation transfer modelling of photodynamic therapy

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Astrophysics at St Andrews:2012 - 2014: Astrophysics at St Andrews: 2012 - 2014

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