Research output per year
Research output per year
Research output
- 11 Article
- 11 results
Search results
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2014
A localized tolerance in the substrate specificity of the fluorinase enzyme enables "last-step" 18F fluorination of a RGD peptide under ambient aqueous conditions
Thompson, S., Zhang, Q., Ónega, M., McMahon, S., Fleming, I., Ashworth, S., Naismith, J., Passchier, J. & O'Hagan, D., 18 Aug 2014, In: Angewandte Chemie International Edition. 53, 34, p. 8913-8918 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Identification of fluorinases from Streptomyces sp MA37, Norcardia brasiliensis, and Actinoplanes sp N902-109 by genome mining
Deng, H., Ma, L., Bandaranayaka, N., Qin, Z., Mann, G., Kyeremeh, K., Yu, Y., Shepherd, T., Naismith, J. H. & O'Hagan, D., 2 Feb 2014, In: ChemBioChem. 15, 3, p. 364-368 5 p.Research output: Contribution to journal › Article › peer-review
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2012
Tryptophan oxygenation: mechanistic considerations
Naismith, J. H., Jun 2012, In: Biochemical Society Transactions. 40, p. 509-514 6 p.Research output: Contribution to journal › Article › peer-review
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2011
Changing the Regioselectivity of the Tryptophan 7-Halogenase PrnA by Site-Directed Mutagenesis
Lang, A., Polnick, S., Nicke, T., William, P., Patallo, E. P., Naismith, J. H. & van Pee, K.-H., 2011, In: Angewandte Chemie International Edition. 50, 13, p. 2951-2953 3 p.Research output: Contribution to journal › Article › peer-review
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2010
The Ternary Complex of PrnB (the Second Enzyme in the Pyrrolnitrin Biosynthesis Pathway), Tryptophan, and Cyanide Yields New Mechanistic Insights into the Indolamine Dioxygenase Superfamily
Zhu, X., van Pee, K.-H. & Naismith, J. H., 2 Jul 2010, In: Journal of Biological Chemistry. 285, 27, p. 21126-21133 8 p.Research output: Contribution to journal › Article › peer-review
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2009
Structural Insights into Regioselectivity in the Enzymatic Chlorination of Tryptophan
Zhu, X., De Laurentis, W., Khim, L., Herrmann, J., Lhiefeld, K., van Pee, K.-H. & Naismith, J. H., 7 Aug 2009, In: Journal of Molecular Biology. 391, 1, p. 74-85 12 p.Research output: Contribution to journal › Article › peer-review
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2008
New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan
Flecks, S., Patallo, E. R., Zhu, X., Ernyei, A. J., Seifert, G., Schneider, A., Dong, C., Naismith, J. H. & van Pee, K.-H., 2008, In: Angewandte Chemie International Edition. 47, p. 9533-9536 4 p.Research output: Contribution to journal › Article › peer-review
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2007
The second enzyme in Pyrrolnitrin Biosynthetic pathway is related to the heme-dependent dioxygenase superfamily
De Laurentis, W., Khim, L., Anderson, J. L. R., Adam, A., Phillips, R. S., Chapman, S. K., van Pee, K.-H. & Naismith, J. H., 30 Oct 2007, In: Biochemistry. 46, 43, p. 12393-12404 12 p.Research output: Contribution to journal › Article › peer-review
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2006
Preliminary crystallographic characterization of PrnB, the second enzyme in the pyrrolnitrin biosynthetic pathway
De Laurentis, W., Leang, K., Hahn, K., Podemski, B., Adam, A., Kroschwald, S., Carter, L., van Pee, K. & Naismith, J. H., Nov 2006, In: Acta Crystallographica. Section F, Structural biology and crystallization communications . 62, Pt 11, p. 1134-1137 4 p.Research output: Contribution to journal › Article › peer-review
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Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates
Cobb, S., Deng, H., McEwan, A., McGlinchey, R., Naismith, J. H., O'Hagan, D. & Robinson, D., Apr 2006, In: Organic & Biomolecular Chemistry. 4, 8, p. 1458-1460 3 p.Research output: Contribution to journal › Article › peer-review
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2005
Tryptophan 7-Halogenase (PrnA) Structure Suggests a Mechanism for Regioselective Chlorination
Dong, C., Flecks, S., Unversucht, S., Haupt, C., Van Pee, K.-H. & Naismith, J. H., 30 Sept 2005, In: Science. 309, 5744, p. 2216-2219 4 p.Research output: Contribution to journal › Article › peer-review