The Human Serine Palmitoyltransferase (SPT) Complex; Specificity, Structure, Regulation and Inhibition

Naismith, Jim (PI)

Project: Standard

Acronym	The Human SPT Complex
Status	Finished
Effective start/end date	31/12/14 → 29/01/18

Funding

Biotechnology and Biological Sciences Research Council: £91,811.00

3 Article

Insights into the mechanism of the cyanobactin heterocyclase enzyme
Ge, Y., Czekster, C. M., Miller, O. K., Botting, C. H., Schwarz-Linek, U. & Naismith, J. H., 23 Apr 2019, In: Biochemistry. 58, 16, p. 2125-2132 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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Using the pimeloyl-CoA synthetase adenylation fold to synthesize fatty acid thioesters
Wang, M., Moynié, L., Harrison, P. J., Kelly, V., Piper, A., Naismith, J. H. & Campopiano, D. J., Jun 2017, In: Nature Chemical Biology. 13, 6, p. 660-667 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
A substrate mimic allows high-throughput assay of the FabA protein and consequently the identification of a novel inhibitor of Pseudomonas aeruginosa FabA
Moynie, L., Hope, A. G., Finzel, K., Schmidberger, J., Leckie, S. M., Schneider, G., Burkart, M. D., Smith, A. D., Gray, D. W. & Naismith, J., 16 Jan 2016, In: Journal of Molecular Biology. 428, 1, p. 108-120 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File

Crystal Structure of 3-hydroxydecanoyl-Acyl Carrier Protein Dehydratase (FabA) from Pseudomonas aeruginosa in complex with N-(4- Chlorobenzyl)-3-(2-furyl)-1H-1,2,4-triazol-5-amine (PDB entry 4CL6)
Moynie, L. (Creator), Hope, A. G. (Creator), Finzel, K. (Creator), Schmidberger, J. (Creator), Leckie, S. M. (Creator), Schneider, G. (Creator), Burkart, M. D. (Creator), Smith, A. D. (Creator), Gray, D. W. (Creator) & Naismith, J. H. (Creator), Protein Data Bank (PDB), 21 Jan 2015
DOI: 10.2210/pdb4CL6/pdb, https://www.rcsb.org/structure/4CL6
Dataset