Research output per year
Research output per year
- 10 results
Search results
-
2019
Structure‐based design, synthesis and biological evaluation of bis‐tetrahydropyran furan acetogenin mimics targeting the trypanosomatid F1 component of ATP synthase
Zacharova, M., Tulloch, L., Gould, E., Fraser, A., King, E., Menzies, S., Smith, T. K. & Florence, G. J., 1 Sept 2019, In: European Journal of Organic Chemistry. 2019, 31-32, p. 5434-5440 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)10 Downloads (Pure) -
2018
Catalytic and anticatalytic snapshots of a short-form ATP phosphoribosyltransferase
Alphey, M. S., Fisher, G., Ge, Y., Gould, E. R., Guerreiro Machado, T. F., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 1 Jun 2018, In: ACS Catalysis. 8, 6, p. 5601-5610 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)13 Downloads (Pure) -
Design and synthesis of broad spectrum trypanosomatid selective inhibitors
Fraser, A. L., Menzies, S. K., King, E. F. B., Tulloch, L., Gould, E. R., Zacharova, M., Smith, T. K. & Florence, G. J., 13 Apr 2018, In: ACS Infectious Diseases. 4, 4, p. 560-567 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Citations (Scopus)8 Downloads (Pure) -
The trypanosome alternative oxidase: a potential drug target?
Menzies, S. K., Tulloch, L. B., Florence, G. J. & Smith, T. K., Feb 2018, In: Parasitology. 145, 2, p. 175-183 9 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile28 Citations (Scopus)6 Downloads (Pure) -
2017
Kinetics and structure of a cold-adapted hetero-octameric ATP phosphoribosyltransferase
Stroek, R., Ge, Y., Talbot, P. D., Glok, M. K., Bernas, K. E., Thomson, C. M., Gould, E. R., Alphey, M. S., Liu, H., Florence, G. J., Naismith, J. H. & da Silva, R. G., 7 Feb 2017, In: Biochemistry. 56, 5, p. 793-803 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)5 Downloads (Pure) -
Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues
Tulloch, L. B., Menzies, S. K., Fraser, A. L., Gould, E. R., King, E. F., Zacharova, M. K., Florence, G. J. & Smith, T. K., 5 Sept 2017, In: PLoS Neglected Tropical Diseases. 11, 9, 28 p., e0005886.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)5 Downloads (Pure) -
Simplifying nature: towards the design of broad spectrum kinetoplastid inhibitors, inspired by acetogenins
Gould, E. R., King, E. F. B., Menzies, S. K., Fraser, A. L., Tulloch, L. B., Zacharova, M. K., Smith, T. K. & Florence, G. J., 15 Nov 2017, In: Bioorganic & Medicinal Chemistry. 25, 22, p. 6126-6136Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)9 Downloads (Pure) -
2016
Development of simplified heterocyclic acetogenin analogues as potent and selective Trypanosoma brucei inhibitors
Florence, G. J., Fraser, A. L., Gould, E. R., King, E. F., Menzies, S. K., Morris, J. C., Thomson, M. I., Tulloch, L. B., Zacharova, M. K. & Smith, T. K., 19 Jul 2016, In: ChemMedChem. 11, 14, p. 1503-1506 4 p.Research output: Contribution to journal › Letter › peer-review
Open AccessFile13 Citations (Scopus)7 Downloads (Pure) -
2014
Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors
Florence, G. J., Fraser, A. L., Gould, E. R., King, E. F. B., Menzies, S. K., Morris, J. C., Tulloch, L. B. & Smith, T. K., Nov 2014, In: ChemMedChem. 9, 11, p. 2548-2556 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)4 Downloads (Pure) -
2013
Total synthesis, stereochemical assignment and biological activity of chamuvarinin and structural analogues
Florence, G. J., Morris, J. C., Murray, R. G., Vanga, R. R., Osler, J. & Smith, T. K., 17 Jun 2013, In: Chemistry - A European Journal. 19, 25, p. 8309-8320 12 p.Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus)