Research output per year
Research output per year
- 12 results
Search results
-
2021
Towards chemical validation of Leishmania infantum ribose 5-phosphate isomerase as a drug target
Dickie, E. A., Ronin, C., Sá, M., Ciesielski, F., Trouche, N., Tavares, J., Santarem, N., Major, L. L., Pemberton, I. K., MacDougall, J., Smith, T. K., Cordeiro-da-Silva, A. & Ciapetti, P., 19 Apr 2021, (E-pub ahead of print) In: Antimicrobial Agents and Chemotherapy. EarlyResearch output: Contribution to journal › Article › peer-review
Open AccessFile -
2019
Biological evaluation and structure activity relationship of 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents
Ashok, P., Chander, S., Smith, T. K., Prakash Singh, R., Nath Jha, P. & Sankaranarayanan, M., Mar 2019, In: Bioorganic Chemistry. 84, p. 98-105Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Structure‐based design, synthesis and biological evaluation of bis‐tetrahydropyran furan acetogenin mimics targeting the trypanosomatid F1 component of ATP synthase
Zacharova, M., Tulloch, L., Gould, E., Fraser, A., King, E., Menzies, S., Smith, T. K. & Florence, G. J., 1 Sept 2019, In: European Journal of Organic Chemistry. 2019, 31-32, p. 5434-5440 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2018
Design, synthesis and biological evaluation of piperazinyl-β-carbolinederivatives as anti-leishmanial agents
Ashok, P., Chander, S., Smith, T. K. & Sankaranarayanan, M., 25 Apr 2018, In: European Journal Of Medicinal Chemistry. 150, p. 559-566 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Design and synthesis of broad spectrum trypanosomatid selective inhibitors
Fraser, A. L., Menzies, S. K., King, E. F. B., Tulloch, L., Gould, E. R., Zacharova, M., Smith, T. K. & Florence, G. J., 13 Apr 2018, In: ACS Infectious Diseases. 4, 4, p. 560-567 8 p.Research output: Contribution to journal › Article › peer-review
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The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: implications to protein function and drug design
Ronin, C., Costa, D. M., Tavares, J., Faria, J., Ciesielski, F., Ciapetti, P., Smith, T. K., MacDougall, J., Cordeiro-da-Silva, A. & Pemberton, I. K., 15 Mar 2018, In: PLoS One. 13, 3, 26 p., e0193602.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2017
Phosphatidylserine synthase 2 and phosphatidylserine decarboxylase are essential for aminophospholipid synthesis in Trypanosoma brucei
Farine, L., Jelk, J., Choi, J.-Y., Voelker, D. R., Nunes, J., Smith, T. K. & Bütikofer, P., May 2017, In: Molecular Microbiology. 104, 3, p. 412-427 16 p.Research output: Contribution to journal › Article › peer-review
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Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana
Mwenechanya, R., Kovářová, J., Dickens, N. J., Mudaliar, M., Herzyk, P., Vincent, I. M., Weidt, S. K., Burgess, K. E., Burchmore, R. J. S., Pountain, A. W., Smith, T. K., Creek, D. J., Kim, D.-H., Lepesheva, G. I. & Barrett, M. P., 16 Jun 2017, In: PLoS Neglected Tropical Diseases. 11, 6, 21 p., e0005649.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2016
Different mutations in a P-type ATPase transporter in Leishmania parasites are associated with cross-resistance to two leading drugs by distinct mechanisms
Fernandez-Prada, C., Vincent, I. M., Brotherton, M.-C., Roberts, M., Roy, G., Rivas, L., Leprohon, P., Smith, T. K. & Ouellette, M., 2 Dec 2016, In: PLoS Neglected Tropical Diseases. 10, 12, 20 p., e0005171.Research output: Contribution to journal › Article › peer-review
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Trypanosoma brucei parasites occupy and functionally adapt to the adipose tissue in mice
Trindade, S., Rijo-Ferreira, F., Carvalho, T., Pinto-Neves, D., Guegan, F., Aresta-Branco, F., Bento, F., Young, S. A., Pinto, A., Van Den Abbeele, J., Ribeiro, R., Dias, S., Smith, T. K. & Figueiredo, L., 8 Jun 2016, In: Cell Host & Microbe. 19, 6, p. 837-848 13 p.Research output: Contribution to journal › Article › peer-review
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2015
Lipidomic analysis of fats and oils – a lot more than just omega-3
Smith, T. K., Jan 2015, In: Lipid Technology. 27, 1, p. 7–10Research output: Contribution to journal › Article › peer-review
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Sugar activation and glycosylation in Plasmodium
Cova, M., Rodrigues, J. A., Smith, T. K. & Izquierdo, L., 31 Oct 2015, In: Malaria Journal. 14, 10 p., 427.Research output: Contribution to journal › Article › peer-review
Open AccessFile