Research output per year
Research output per year
- 18 results
Search results
-
2021
An expedient, mild and aqueous method for Suzuki–Miyaura diversification of (hetero)aryl halides or (poly)chlorinated pharmaceuticals
Sharma, S. V., Pubill-Ulldemolins, C., Marelli, E. & Goss, R. J. M., 21 Oct 2021, In: Organic Chemistry Frontiers. 8, 20, p. 5722-5727Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)10 Downloads (Pure) -
GenoChemetic strategy for derivatization of the violacein natural product scaffold
Lai, H.-E., Obled, A. M. C., Chee, S. M., Morgan, R. M., Lynch, R., Sharma, S. V., Moore, S. J., Polizzi, K. M., Goss, R. J. M. & Freemont, P. S., 14 Oct 2021, (E-pub ahead of print) In: ACS Chemical Biology. Articles ASAP, 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)10 Downloads (Pure) -
Halogenases: a palette of emerging opportunities for synthetic biology–synthetic chemistry and C–H functionalisation
Crowe, C., Molyneux, S., Sharma, S. V., Zhang, Y., Gkotsi, D. S., Connaris, H. & Goss, R. J. M., 7 Sept 2021, In: Chemical Society Reviews. 17, 50, p. 9443-9481 39 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile58 Citations (Scopus)36 Downloads (Pure) -
SynBio-SynChem approaches to diversifying the pacidamycins through the exploitation of an observed Pictet-Spengler reaction
Cartmell, C., Abou Fayad, A., Lynch, R., Sharma, S., Hauck, N., Gust, B. & Goss, R. J. M., 15 Feb 2021, In: ChemBioChem. 22, 4, p. 712-716 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile9 Downloads (Pure) -
2020
Halogenases: structures and functions
Ludewig, H., Molyneux, S., Ferrinho, S., Guo, K., Lynch, R., Gkotsi, D. S. & Goss, R. J., Dec 2020, In: Current Opinion in Structural Biology. 65, p. 51-60 10 p.Research output: Contribution to journal › Review article › peer-review
21 Citations (Scopus) -
Phenylalanine meta-hydroxylase: a single residue mediates mechanistic control of aromatic amino acid hydroxylation
Gruschow, S., Sadler, J., Sharrat, P. & Goss, R. J. M., 3 Feb 2020, In: ChemBioChem. 21, 3, p. 417-422Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)11 Downloads (Pure) -
2019
A marine viral halogenase that iodinates diverse substrates
Gkotsi, D. S., Ludewig, H., Sharma, S. V., Connolly, J. A., Dhaliwal, J., Wang, Y., Unsworth, W. P., Taylor, R. J. K., McLachlan, M. M. W., Shanahan, S., Naismith, J. H. & Goss, R. J. M., 14 Oct 2019, In: Nature Chemistry. 11, 12, p. 1091–1097 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile68 Citations (Scopus)11 Downloads (Pure) -
A natural solution to photoprotection and isolation of the potent polyene antibiotic, marinomycin A
Bailey, C. S., Zarins-Tutt, J. S., Agbo, M., Gao, H., Diego-Taboada, A., Gan, M., Hamed Farghal, R. B., Abraham, E., Mackenzie, G., Evans, P. A. & Goss, R. J. M., 28 Aug 2019, In: Chemical Science. 10, 32, p. 7549-7553 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)7 Downloads (Pure) -
Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions
Renault, Y. J. G., Lynch, R., Marelli, E., Sharma, S. V., Pubill Ulldemolins, C., Sharp, J., Cartmell, C., Cárdenas, P. & Goss, R. J. M., 8 Oct 2019, (E-pub ahead of print) In: Chemical Communications. Advance Article, 4 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile10 Citations (Scopus)9 Downloads (Pure) -
Heck diversification of indole‐based substrates under aqueous conditions: from indoles to unprotected halo‐tryptophans and halo‐tryptophans in natural product derivatives
Pubill-Ulldemolins, C., Sharma, S. V., Cartmell, C., Zhao, J., Cárdenas, P. & Goss, R. J. M., 14 Aug 2019, In: Chemistry - A European Journal. 25, 46, p. 10866-10875 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)5 Downloads (Pure) -
2018
Halogenases: powerful tools for biocatalysis (mechanisms applications and scope)
Gkotsi, D. S., Dhaliwal, J., McLachlan, M. M. W., Mulholand, K. R. & Goss, R. J. M., Apr 2018, In: Current Opinion in Chemical Biology. 43, p. 119-126 8 p.Research output: Contribution to journal › Review article › peer-review
56 Citations (Scopus) -
2017
A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules
Reed, J., Stephenson, M. J., Miettinen, K., Brouwer, B., Leveau, A., Brett, P., Goss, R. J. M., Goossens, A., O’Connell, M. A. & Osbourn, A., Jul 2017, In: Metabolic Engineering. 42, p. 185-193 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile144 Citations (Scopus)8 Downloads (Pure) -
Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo
Sharma, S. V., Tong, X., Pubill-Ulldemolins, C., Cartmell, C., Bogosyan, E. J. A., Rackham, E. J., Marelli, E., Hamed, R. B. & Goss, R. J. M., 9 Aug 2017, In: Nature Communications. 8, 10 p., 229.Research output: Contribution to journal › Article › peer-review
Open AccessFile56 Citations (Scopus)10 Downloads (Pure) -
Mild, aqueous α-arylation of ketones: towards new diversification tools for halogenated metabolites and drug molecules
Marelli, E., Renault, Y., Sharma, S. V., Nolan, S. P. & Goss, R. J. M., 17 Mar 2017, In: Chemistry - A European Journal. 23, 16, p. 3832-3836 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile22 Citations (Scopus)5 Downloads (Pure) -
Sonogashira diversification of unprotected halotryptophans, halotryptophan containing tripeptides; and generation of a new to nature bromo-natural product and its diversification in water
Corr, M. J., Sharma, S. V., Pubill Ulldemolins, C., Bown, R. T., Poirot, P., Smith, D. R. M., Cartmell, C., Abou Fayad, A. & Goss, R. J. M., 1 Mar 2017, In: Chemical Science. 8, 3, p. 2039-2046 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile34 Citations (Scopus)6 Downloads (Pure) -
2016
One-pot access to L-5,6-dihalotryptophans and L-alknyltryptophans using tryptophan synthase
Corr, M. J., Smith, D. R. M. & Goss, R. J. M., 17 Nov 2016, In: Tetrahedron. 72, 46, p. 7306-7310 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)7 Downloads (Pure) -
Rapid enzyme regeneration results in the striking catalytic longevity of an engineered, single species, biocatalytic biofilm
Tong, X., Barberi, T. T., Botting, C. H., Sharma, S. V., Simmons, M. J. H., Overton, T. W. & Goss, R. J. M., 21 Oct 2016, In: Microbial Cell Factories. 15, 1, 11 p., 180.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)6 Downloads (Pure) -
2015
Promiscuous indolyl vinyl isonitrile synthases in the biogenesis and diversification of hapalindole-type alkaloids
Ittiamornkul, K., Zhu, Q., Gkotsi, D. S., Smith, D. R. M., Hillwig, M., Nightingale, N., Goss, R. J. M. & Liu, X., 2015, In: Chemical Science. In pressResearch output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)9 Downloads (Pure)