Project Details
| Acronym | CBASS |
|---|---|
| Status | Active |
| Effective start/end date | 22/04/21 → 21/04/26 |
Funding
- European Research Council: £1,384,046.15
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
Research output
- 16 Article
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Structure and mechanism of the broad spectrum CRISPR-associated ring nuclease Crn4
Chi, H., Hoikkala, V., McMahon, S., Graham, S., Gloster, T. & White, M., 23 Jan 2026, In: Nature Communications. 17, p. 1-10 10 p., 889.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A viral SAVED protein with ring nuclease activity degrades the CRISPR second messenger cA4
Orzechowski, M. G., Hoikkala, V., Chi, H., McMahon, S., Gloster, T. & White, M., Nov 2025, In: Biochemical Journal. 482, 22, p. 1-13 13 p., BCJ20253271.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Cas10 based 7SL-sRNA diagnostic for the detection of active trypanosomiasis
Gruschow, S., Steketee, P. C., Paxton, E., Matthews, K. R., Morrison, L. J., White, M. F. & Grey, F., 17 Mar 2025, In: PLoS Neglected Tropical Diseases. 19, 3, p. 1-17 17 p., e0012937.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Datasets
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Bioinformatic analysis of type III CRISPR systems reveals key properties and new effector families (code)
White, M. (Creator), Hoikkala, V. P. (Creator) & Graham, S. (Creator), GitHub, 2024
https://vihoikka.github.io/type_iii_crispr_browser/ and one more link, https://github.com/vihoikka/hoikkala_etal_typeIII_effectors (show fewer)
Dataset: Software
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Antiviral signaling by a cyclic nucleotide activated CRISPR protease (crystal structures)
Chi, H. (Creator) & White, M. (Creator), Protein Data Bank (PDB), 2022
DOI: 10.2210/pdb7qda/pdb, https://doi.org/10.2210/pdb8B0R/pdb and one more link, https://doi.org/10.2210/pdb8B0U/pdb (show fewer)
Dataset
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Antiviral signaling by a cyclic nucleotide activated CRISPR protease (SAXS data and models)
Chi, H. (Creator) & White, M. (Creator), Small Angle Scattering Biological Data Bank (SASBDB), 2022
https://www.sasbdb.org/data/SASDQM4 and 3 more links, https://www.sasbdb.org/data/SASDQN4, https://www.sasbdb.org/data/SASDQP4, https://www.sasbdb.org/data/SASDQQ4 (show fewer)
Dataset