Deciphering mechanisms underlying the dysfunction of motoneorons derived from ALS patient iPSCs

Miles, Gareth (PI)

School of Psychology and Neuroscience

Project: Studentship

Acronym	MNDA Studentship
Status	Finished
Effective start/end date	27/09/15 → 26/09/18

Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology
Zhao, C., Devlin, A.-C., Chouhan, A. K., Selvaraj, B., Stavrou, M., Burr, K., Brivio, V., He, X., Mehta, A., Story, D., Shaw, C., Dando, O., Hardingham, G., Miles, G. B. & Chandran, S., 11 Mar 2020, In: Glia. 68, 5, p. 1046-1064 19 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca²⁺-permeable AMPA receptor-mediated excitotoxicity
Thangaraj Selvaraj , B., Livesey , M., Zhao , C., Gregory , J., James, O., Cleary, E., Chouhan, A. K., Gane, A., Perkins, E., Dando, O., Lillico, S., Lee, Y.-B., Nishimura, A., Poreci, U., Thankamony, S., Pray, M., Vasistha, N., Magnani, D., Borooah, S. & Burr, K. & 12 others, Story, D., McCampbell, A., Shaw, C., Kind, P., Aitman, T. J., Whitelaw, B., Wilmut, I., Smith, C., Miles, G. B., Hardingham, G., Wyllie, D. & Chandran, S., 24 Jan 2018, In: Nature Communications. 9, 14 p., 347.
Research output: Contribution to journal › Article › peer-review

Open Access
File

Invited talk "Astrocytes of the spinal cord in health and disease" - Institute for Neurosciences, Inserm/University of Montpellier, France
Miles, G. B. (Speaker)
15 Sept 2022
Activity: Talk or presentation types › Invited talk
Keynote talk: "Functional analyses of human iPSC-based models of ALS reveal potential pathogenic mechanisms" - Neurofrance satellite symposium: "The spinal cord: Basic research to clinical practice", Marseille, France.
Miles, G. B. (Speaker)
21 May 2019
Activity: Talk or presentation types › Invited talk
Invited talk "Astrocytes of the spinal cord in health and disease; best laid schemes of mice and men” - Department of Neurobiology and Anatomy, Drexel University, Philadelphia, USA
Miles, G. B. (Speaker)
20 Mar 2019
Activity: Talk or presentation types › Invited talk