Personal profile
Research overview
Metabolism and Biomarkers Lab
Our research is dedicated to identifying specific metabolic alterations in cancer to drive biomarker discovery and develop innovative therapeutic strategies. By utilizing LC-MS-based metabolomics, we explore potential biomarkers and therapeutic targets for Hepatocellular Carcinoma, Soft Tissue Sarcoma, and Esophageal Cancer. Our goal is to advance cancer diagnostics and treatment through a deeper understanding of tumor metabolism.
Keywords
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
- Cancer Metabolism
- LCMS Metabolomics
- Cell Signaling
- Autophagy
- Hepatocellular Carcinoma
- Soft Tissue Sarcoma
- Esophageal Cancer
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Steroid-dependent metabolic rewiring reveals novel therapeutic and imaging approaches for glioblastoma
Allega, M. F., Deshmukh, R., Hillinger, T., Akhmetshina, A., Oudin, A., Bielik, R., Soloviev, D., Villar, V. H., Ackermann, T., Bourmeau, G., Chahal, S. K., Stevenson, K. H., Nixon, C., Shaw, R., Morrison, G. M., Chalmers, A. J., Pollard, S. M., Lund-Johansen, M., Bjerkvig, R. & Seano, G. & 5 others, , 23 Jan 2026, In: Science Advances. 12, 4, p. 1-17 17 p., eadx6539.Research output: Contribution to journal › Article › peer-review
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Editorial: Metabolic alterations in cancer: from targeting metabolism to cancer detection
Ackermann, T., Deshmukh, R., Echeverria, C., Santibanez, J. F. & Villar, V. H., 30 Jul 2025, In: Frontiers in Cell and Developmental Biology. 13, p. 1-2 2 p., 1661985.Research output: Contribution to journal › Editorial › peer-review
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Breast cancer secretes anti-ferroptotic MUFAs and depends on selenoprotein synthesis for metastasis
Ackermann , T., Shokry, E., Deshmukh, R., Anand, J., Galbraith, L. C. A., Mitchell, L., Rodriguez-Blanco, G., Villar, V. H., Sterken, B. A., Nixon, C., Zanivan, S., Blyth, K., Sumpton, D. & Tardito, S., 11 Nov 2024, In: Embo Molecular Medicine. 16, 11, p. 2749-2774 26 p.Research output: Contribution to journal › Article › peer-review
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Current and future cancer chemoprevention strategies
Santibanez, J. F., Villar, V. H. & Echeverria, C., 19 May 2023, In: Pharmaceutics. 15, 5, 5 p., 1543.Research output: Contribution to journal › Editorial › peer-review
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Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer
Villar, V., Allega, M., Deshmukh, R., Ackermann, T., Nakasone, M., Vande Voorde, J., Drake, T., Oetjen, J., Bloom, A., Nixon, C., Müller, M., May, S., Tan, E., Vereecke, L., Jans, M., Blancke, G., Murphy, D., Huang, D., Lewis, D. & Bird, T. & 4 others, , Mar 2023, In: Nature Chemical Biology. 19, 3, p. 292-304 13 p.Research output: Contribution to journal › Article › peer-review
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