Uli Schwarz-Linek

2025

ISG15-dependent stabilisation of USP18 is necessary but not sufficient to regulate type I interferon signalling in humans

Vasou, A., Nightingale, K., Cetkovská , V., Scheler, J., Bamford, C. G. G., Andrejeva, J., Rowe, J. C., Swatek, K. N., Schwarz-Linek, U., Randall, R. E., McLauchlan, J., Weekes, M. P., Bogunovic, D. & Hughes, D. J., 11 Feb 2025, In: European Journal of Immunology. 55, 2, 16 p., e202451651.

Research output: Contribution to journal › Article › peer-review

Open Access

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Recombinant production platform for Group A Streptococcus glycoconjugate vaccines

Ajay Castro, S., Passmore, I. J., Ndeh, D., Shaw, H. A., Ruda, A., Burns, K., Thomson, S., Nagar, R., Alagesan, K., Reglinski, M., Lucas, K., Abouelhadid, S., Schwarz-Linek, U., Mawas, F., Widmalm, G., Wren, B. W. & Dorfmueller, H. C., 22 Jan 2025, In: npj Vaccines. 10, p. 1-14 14 p., 16.

Research output: Contribution to journal › Article › peer-review

Open Access

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2023

Structural and biochemical characterisation of Co²⁺-binding sites on serum albumins and their interplay with fatty acids

Wu, D., Gucwa, M., Czub, M. P., Cooper, D. R., Shabalin, I. G., Fritzen, R., Arya, S., Schwarz-Linek, U., Blindauer, C. A., Minor, W. & Stewart, A. J., 21 Jun 2023, In: Chemical Science. 14, 23, p. 6244-6258 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2019

Insights into the mechanism of the cyanobactin heterocyclase enzyme

Ge, Y., Czekster, C. M., Miller, O. K., Botting, C. H., Schwarz-Linek, U. & Naismith, J. H., 23 Apr 2019, In: Biochemistry. 58, 16, p. 2125-2132 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2018

A new structural class of bacterial thioester domains reveals a slipknot topology

Miller, O. K., Banfield, M. & Schwarz-Linek, U., Sept 2018, In: Protein Science. 27, 9, p. 1651-1660

Research output: Contribution to journal › Article › peer-review

Open Access

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Oxidation of the cyanobactin precursor peptide is independent of the leader peptide and operates in a defined order

Gao, S., Ge, Y., Bent, A. F., Schwarz-Linek, U. & Naismith, J. H., 16 Oct 2018, In: Biochemistry. 57, 41, p. 5996-6002 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

A new method for post-translationally labeling proteins in live cells for fluorescence imaging and tracking

Hinrichsen, M., Lenz, M., Edwards, J. M., Miller, O. K., Mochrie, S. G. J., Swain, P. S., Schwarz-Linek, U. & Regan, L., Dec 2017, In: Protein Engineering, Design & Selection. 30, 12, p. 771-780

Research output: Contribution to journal › Article › peer-review

Open Access

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Rift Valley fever phlebovirus NSs protein core domain structure suggests molecular basis for nuclear filaments

Barski, M., Brennan, B., Miller, O. K., Potter, J. A., Vijayakrishnan, S., Bhella, D., Naismith, J. H., Elliott, R. M. & Schwarz-Linek, U., 15 Sept 2017, In: eLife. 6, 20 p., e29236.

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

An internal thioester in a pathogen surface protein mediates covalent host binding

Walden, M., Edwards, J. M., Dziewulska, A. M., Bergmann, R., Saalbach, G., Kan, S.-Y., Miller, O. K., Weckener, M., Jackson, R. J., Shirran, S. L., Botting, C. H., Florence, G. J., Rohde, M., Banfield, M. J. & Schwarz-Linek, U., 2 Jun 2015, In: eLife. 4, 24 p., e06638.

Research output: Contribution to journal › Article › peer-review

Open Access

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Plasma free fatty acid levels influence Zn²⁺-dependent histidine-rich glycoprotein-heparin interactions via an allosteric switch on serum albumin

Kassaar, O., Schwarz-Linek, U., Blindauer, C. A. & Stewart, A. J., Jan 2015, In: Journal of Thrombosis and Haemostasis. 13, 1, p. 101-110 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2014

An efficient method for the in vitro production of Azol(in)e-based cyclic peptides

Houssen, W. E., Bent, A. F., McEwan, A. R., Pieiller, N., Tabudravu, J., Koehnke, J., Mann, G., Adaba, R. I., Thomas, L., Hawas, U. W., Liu, H., Schwarz-Linek, U., Smith, M. C. M., Naismith, J. H. & Jaspars, M., 15 Dec 2014, In: Angewandte Chemie International Edition. 53, 51, p. 14171-14174 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Covalent host-targeting by thioester domains of Gram-positive pathogens

Walden, M., Edwards, J., Dziewulska, A., Schwarz-Linek, U. & Banfield, M., 1 Aug 2014, In: Acta Crystallographica Section A: Foundations and Advances. 70, a1, p. C848

Research output: Contribution to journal › Article › peer-review

The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster

Mann, G., Koehnke, J. A. J. G., Bent, A. F., Graham, R., Houssen, W., Jaspars, M., Schwarz-Linek, U. & Naismith, J., Dec 2014, In: Acta Crystallographica. Section F, Structural biology and crystallization communications . F70, p. 1597-1603 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Yet more intramolecular cross-links in Gram-positive surface proteins

Schwarz-Linek, U. & Banfield, M. J., 28 Jan 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 4, p. 1229-1230 2 p.

Research output: Contribution to journal › Editorial › peer-review

2013

The cyanobactin heterocyclase enzyme: A processive adenylase that operates with a defined order of reaction

Koehnke, J. A. J. G., Bent, A. F., Zollman, D., Smith, K., Houssen, W. E., Zhu, X., Mann, G., Lebl, T., Scharff, R., Shirran, S. L., Botting, C. H., Jaspers, M., Schwarz-Linek, U. & Naismith, J., Dec 2013, In: Angewandte Chemie International Edition. 52, 52, p. 13991-13996 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2012

Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesin

Zakeri, B., Fierer, J. O., Celik, E., Chittock, E. C., Schwarz-Linek, U., Moy, V. T. & Howarth, M., 20 Mar 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 12, p. E690-E697 8 p.

Research output: Contribution to journal › Article › peer-review

2011

Cooperative Binding and Activation of Fibronectin by a Bacterial Surface Protein

Marjenberg, Z. R., Ellis, I. R., Hagan, R. M., Prabhakaran, S., Höök, M., Talay, S. R., Potts, J. R., Staunton, D. & Schwarz-Linek, U., 21 Jan 2011, In: Journal of Biological Chemistry. 286, 3, p. 1884-1894 11 p.

Research output: Contribution to journal › Article › peer-review

2010

Implications for collagen binding from the crystallographic structure of fibronectin 6FnI1-2FnII7FnI.

Erat, M., Schwarz-Linek, U., Pickford, A., Farndale, R., Campbell, I. & Vakonakis, I., Aug 2010, In: Journal of Biological Chemistry. 285, 44, p. 33764-33770 7 p.

Research output: Contribution to journal › Article › peer-review

NMR spectroscopic and theoretical analysis of a spontaneously formed Lys-Asp isopeptide bond

Hagan, R. M., Bjornsson, R., McMahon, S., Schomburg, B., Braithwaite, V., Buehl, M., Naismith, J. & Schwarz-Linek, U., Nov 2010, In: Angewandte Chemie International Edition. 49, 45, p. 8421-8425 5 p.

Research output: Contribution to journal › Article › peer-review

The helicase XPD unwinds bubble structures and is not stalled by DNA lesions removed by the nucleotide excision repair pathway

Rudolf, J., Rouillon, C., Schwarz-Linek, U. & White, M. F., Jan 2010, In: Nucleic Acids Research. 38, 3, p. 931-941 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The Scottish Structural Proteomics Facility: targets, methods and outputs

Oke, M., Carter, L., Johnson, K., Liu, H., McMahon, S., Yan, X., Kerou, M., Weikart, N., Kadi, N., Sheikh, M., Schmelz, S., Dorward, M., Zawadzki, M., Cozens, C., Falconer, H., Powers, H., Overton, I., van Niekerk, C., Peng, X. & Patel, P. & 11 others, Garrett, R., Prangishvili, D., Botting, C., Coote, P., Dryden, D., Barton, G., Schwarz-Linek, U., Challis, G., Taylor, G., White, M. & Naismith, J., 1 Jun 2010, In: Journal of Structural and Functional Genomics. 11, 2, p. 167-180

Research output: Contribution to journal › Article › peer-review

Open Access

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The Streptococcal Binding Site in the Gelatin-binding Domain of Fibronectin Is Consistent with a Non-linear Arrangement of Modules

Atkin, K. E., Brentnall, A. S., Harris, G., Bingham, R. J., Erat, M. C., Millard, C. J., Schwarz-Linek, U., Staunton, D., Vakonakis, I., Campbell, I. D. & Potts, J. R., 19 Nov 2010, In: Journal of Biological Chemistry. 285, 47, p. 36977-36983 7 p.

Research output: Contribution to journal › Article › peer-review

2008

Crystal structures of fibronectin-binding sites from Staphylococcus aureus FnBPA in complex with fibronectin domains

Bingham, R., Rudino-Pinera, E., Meenan, N., Schwarz-Linek, U., Turkenburg, J., Hook, M., Garman, E. & Potts, J., 26 Aug 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 34, p. 12254-12258 5 p.

Research output: Contribution to journal › Article › peer-review

2007

CC1, a novel crenarchaeal DNA binding protein

Luo, X., Schwarz-Linek, U., Botting, C. H., Hensel, R., Siebers, B. & White, M. F., Jan 2007, In: Journal of Bacteriology. 189, p. 403-409 7 p.

Research output: Contribution to journal › Article › peer-review

The Solution and Crystal Structures of a Module Pair from the Staphylococcus aureus-Binding Site of Human Fibronectin-A Tale with a Twist.

Rudino-Pinera, E., Ravelli, R., Sheldrick, G., Nanao, M., Korostelev, V., Werner, J., Schwarz-Linek, U., Potts, J. & Garman, E., 4 May 2007, In: Journal of Molecular Biology. 368, 3, p. 833-844 12 p.

Research output: Contribution to journal › Article › peer-review

The tandem beta -zipper model defines high affinity fibronectin-binding repeats within Staphylococcus aureus FnBPA

Meenan, N., Visai, L., Valtulina, V., Schwarz-Linek, U., Norris, N., Gurusidappa, S., Höök, M., Speziale, P. & Potts, J., 31 Aug 2007, In: Journal of Biological Chemistry. 282, 35, p. 25893-25902 10 p.

Research output: Contribution to journal › Article › peer-review

2006

Fibronectin-binding proteins of Gram-positive cocci

Schwarz-Linek, U., Höök, M. & Potts, J. R., Jul 2006, In: Microbes and Infection. 8, 8, p. 2291-2298 8 p.

Research output: Contribution to journal › Article › peer-review

Structural insight into binding of Staphylococcus aureus to human fibronectin.

Pilka, E., Werner, J., Schwarz-Linek, U., Pickford, A., Meenan, N., Campbell, I. & Potts, J., 9 Jan 2006, In: FEBS Letters. 580, p. 273-277 5 p.

Research output: Contribution to journal › Article › peer-review

2005

Borrelia burgdorferi binds fibronectin through a tandem β-zipper, a common mechanism of fibronectin binding in staphylococci, streptococci and spirochetes

Raibaud, S., Schwarz-Linek, U., Kim, J. H., Jenkins, H. T., Baines, E. R., Gurusiddappa, S., Höök, M. & Potts, J. R., 13 May 2005, In: Journal of Biological Chemistry. 280, 19, p. 18803-18809 7 p.

Research output: Contribution to journal › Article › peer-review

2004

BBK32, a fibronectin-binding MSCRAMM from Borrelia burgdorferi contains a disordered region that undergoes a conformational change on ligand binding.

Kim, J., Singvall, J., Schwarz-Linek, U., Johnson, B., Potts, J. & Höök, M., 1 Oct 2004, In: Journal of Biological Chemistry. 279, p. 41706-41714 9 p.

Research output: Contribution to journal › Article › peer-review

High affinity streptococcal binding to human fibronectin requires specific recognition of sequential F1 modules

Schwarz-Linek, U., Pilka, E. S., Pickford, A. R., Kim, J. H., Höök, M., Campbell, I. D. & Potts, J. R., 10 Sept 2004, In: Journal of Biological Chemistry. 279, 37, p. 39017-39025 9 p.

Research output: Contribution to journal › Article › peer-review

The molecular basis of fibronectin-mediated bacterial adherence to host cells

Schwarz-Linek, U., Höök, M. & Potts, J. R., May 2004, In: Molecular Microbiology. 52, p. 631-641 11 p.

Research output: Contribution to journal › Article › peer-review

Twinned or not twinned, that is the question: crystallization and preliminary crystallographic analysis of the ²F1³F1 module pair of human fibronectin.

Rudiño-Piñera, E., Schwarz-Linek, U., Potts, J. R. & Garman, E. F., Jul 2004, In: Acta Crystallographica. Section D, Biological crystallography. 60, p. 1341-1345 5 p.

Research output: Contribution to journal › Article › peer-review

2003

Pathogenic bacteria attach to human fibronectin through a tandem β-zipper

Schwarz-Linek, U., Werner, J. M., Pickford, A. R., Gurusiddappa, S., Kim, J. H., Pilka, E. S., Briggs, J. A. G., Gough, T. S., Höök, M., Campbell, I. D. & Potts, J. R., 8 May 2003, In: Nature. 423, 6936, p. 177-181 5 p.

Research output: Contribution to journal › Article › peer-review

2001

Binding of a peptide from a Streptococcus dysgalactiae MSCRAMM to the N-terminal F1 module pair of human fibronectin involves both modules

Schwarz-Linek, U., Plevin, M., Pickford, A., Hook, M., Campbell, I. & Potts, J., 25 May 2001, In: FEBS Letters. 497, 2-3, p. 137-140 4 p.

Research output: Contribution to journal › Article › peer-review

Synthesis of natural product precursors by Baeyer-Villiger oxidation with cyclohexanone monooxygenase from Acinetobacter

Schwarz-Linek, U., Krodel, A., Ludwig, F., Schulze, A., Rissom, S., Kragl, U., Tishkov, V. & Vogel, M., May 2001, In: Synthesis. 6, p. 947-951 5 p.

Research output: Contribution to journal › Article › peer-review

1997

Synthesis of chiral epsilon-lactones in a two-enzyme system of cyclohexanone mono-oxygenase and formate dehydrogenase with integrated bubble-free aeration

Rissom, S., Schwarz-Linek, U., Vogel, M., Tishkov, V. & Kragl, U., 14 Aug 1997, In: Tetrahedron: Asymmetry. 8, 15, p. 2523-2526 4 p.

Research output: Contribution to journal › Article › peer-review

Uli Schwarz-Linek

Research output

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